Hacettepe Üniversitesi Açık Erişim Sistemi (HÜAES)
- HÜAES, Hacettepe Üniversitesi bünyesinde üretilen kitap, makale, tez, bildiri, rapor gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Communities in DSpace
Select a community to browse its collections.
- Ankara State Conservatory
- Directorates
- Faculty of Dentistry
- Faculty of Pharmacy
- Faculty of Letters
Recent Submissions
ERKEK ÜROGENİTAL DİSTRES ENVANTERİ VE ERKEK ÜRİNER SEMPTOM ETKİ ANKETİ’NİN TÜRKÇE GEÇERLİK VE GÜVENİRLİK ÇALIŞMASI
(Sağlık Bilimleri Enstitüsü, 2026) Güngör Ömer; Cerrahi Hastalıkları Hemşireliği
This methodological study was conducted to adapt the Male Urogenital Distress Inventory (MUDI) and the Male Urinary Symptom Impact Questionnaire (MUSIQ) to Turkish culture and to examine their validity and reliability. The study included 300 male patients presenting with lower urinary tract symptoms (LUTS), and the test–retest evaluation was completed with 79 participants. Descriptive statistics, the content validity index, exploratory and confirmatory factor analyses, Pearson correlation analysis, Cronbach’s alpha coefficients, corrected item-total correlations, and the intraclass correlation coefficients were used in the data analysis. Following translation, expert review, and pilot testing, the content validity indices were found to be 0.995 for the Turkish form of the MUDI (EÜDE) and 0.978 for the Turkish form of the MUSIQ (EÜSEA). Exploratory factor analysis showed that EÜDE consisted of 21 items and three subdimensions (Voiding, Storage, and Incontinence), whereas EÜSEA consisted of 27 items and three subdimensions (Psychosocial Impact, Impact on Daily Life, and Activity and Functioning); both structures were confirmed by confirmatory factor analysis (χ²/df = 2.784 and 2.657; RMSEA = 0.077 and 0.074, respectively). Convergent validity analyses revealed a statistically significant positive correlation between the total scores of EÜDE and ICIQ-MLUTS (r = 0.735) and a statistically significant negative correlation between the total scores of EÜSEA and I-QOL (r = −0.829) (p <0.001). The Cronbach’s alpha internal consistency coefficients were 0.846 for EÜDE and 0.953 for EÜSEA. In the four-week test–retest evaluation, the intraclass correlation coefficients were 0.996 for EÜDE and 0.973 for EÜSEA (p <0.001). In conclusion, the Turkish forms of both measurement instruments were determined to be valid and reliable tools for evaluating the distress caused by LUTS and its impact on quality of life in the male patient population.
Prediyabetli ve Tip 2 Diyabetli Bireylerde Diyet Polifenol Alım Düzeyleri ve Diyetin İnflamatuar İndeksinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2026) Yıldırım Pınar, Sümeyra; Toplu Beslenme Sistemleri
Yıldırım Pınar S., Evaluation of Dietary Polyphenol Intake Levels and Dietary Inflammatory Index in Individuals with Prediabetes and Type 2 Diabetes, Hacettepe University Gradute School of Health Sciences Department of Food Service Systems Master’s Thesis, Ankara, 2026. The protective effects of a polyphenol-rich diet in the prevention and management of diabetes have been gaining increasing importance. Accordingly, this study was conducted on a total of 150 adult individuals (50 healthy controls, 50 individuals with prediabetes, and 50 individuals with type 2 diabetes) with the aim of evaluating dietary polyphenol intake levels and the Dietary Inflammatory Index (DII) in healthy individuals, individuals with prediabetes, and individuals with type 2 diabetes. Participants' sociodemographic characteristics, dietary habits, and physical activity levels were assessed using a questionnaire, while anthropometric measurements were obtained and biochemical parameters were recorded. Participants' dietary polyphenol intake was determined using the Polyphenol Consumption Frequency Questionnaire, and DII scores were calculated from 24-hour dietary records. A significant difference was found among the groups in terms of total polyphenol intake, with the control group having higher polyphenol intake than the prediabetes and type 2 diabetes groups (p<0.001). Similarly, a significant difference was found among the groups in terms of flavonoid intake, and the control group had higher flavonoid intake than the type 2 diabetes group (p=0.028). No statistically significant difference was found between sexes in terms of polyphenol intake levels (p>0.05). The DII scores of the prediabetes group were found to be higher than those of the control group (p=0.029). When the relationships between polyphenol intake and anthropometric measurements were examined, significant negative correlations were identified between total polyphenol intake and BMI (r=-0.208; p=0.011), body weight (r=-0.170; p=0.038), and waist-to-hip ratio (r=-0.232; p=0.040). Negative correlations were also found between flavonoid and stilbene intake and BMI (p<0.05). According to the evaluation based on total polyphenol intake tertiles, individuals in the highest polyphenol intake tertile were found to have significantly lower waist-to-hip ratios (p=0.013). When the biochemical findings were evaluated, negative correlations were found between total polyphenol intake and fasting blood glucose (r=-0.345; p<0.01), HbA1c (r=-0.111; p=0.001), and triglyceride levels (r=-0.143; p=0.048). Negative correlations were also identified between phenolic acid, flavonoid, stilbene, and lignan intake and fasting blood glucose (p<0.05). A positive correlation was found between HDL cholesterol levels and flavonoid intake (r=0.189; p=0.021). According to the evaluation based on total polyphenol intake tertiles, individuals in the highest polyphenol intake tertile were found to have lower fasting blood glucose levels and higher HDL cholesterol levels (p<0.05). A significant negative correlation was found between total polyphenol intake and DII (p=0.030), indicating that higher polyphenol consumption was associated with diets having lower inflammatory potential. Consequently, higher polyphenol consumption was associated with better glycemic control, higher HDL cholesterol levels, lower indicators of abdominal obesity, and lower dietary inflammatory scores. The findings obtained indicate that a polyphenol-rich diet may provide potential benefits in the prevention and management of prediabetes and type 2 diabetes.
Romatoid Artritli Bireylerde Hareket İmgeleme Anketi-3 ve Kinestetik ve Görsel İmgelemeAnketi-20'nin Psikometrik Özelliklerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2026-08-03) Gamze OZAN BÜYÜKŞİMŞEK; Fizyoterapi ve Rehabilitasyon
Ozan Buyuksimsek, G., Investigation of the Psychometric Properties of the Movement Imagery Questionnaire-3 and the Kinesthetic and Visual Imagery Questionnaire-20 in Individuals with Rheumatoid Arthritis, Hacettepe University, Graduate School of Health Sciences, Rheumatological Physiotherapy and Rehabilitation Program, Master of Science Thesis, Ankara, 2026. The primary aim of this study was to examine the validity and reliability of the Turkish versions of the Movement Imagery Questionnaire-3 (MIQ-3) and the Kinesthetic and Visual Imagery Questionnaire-20 (KVIQ-20) in individuals with rheumatoid arthritis. The secondary aim was to examine the motor imagery skills of individuals with rheumatoid arthritis. A total of 149 individuals were included in the study, consisting of individuals with rheumatoid arthritis (n = 109) aged between 20 and 65 years and healthy individuals (n = 40) aged between 22 and 65 years. Test-retest reliability (ICC), internal consistency (Cronbach's alpha), Bland-Altman analysis, and construct validity were evaluated. In addition, known-groups/discriminant validity and convergent-discriminant validity with selected clinical, psychosocial, and cognitive measures were examined using Spearman correlations. The test-retest reliability of the MIQ-3 was ICC = 0.809 and its internal consistency was Cronbach's alpha = 0.930, with factor analyses supporting a single-factor structure. ROC analysis showed that the MIQ-3 had low discriminative performance that did not reach statistical significance (AUC = 0.604; p = 0.053). The KVIQ-20 total and subscale scores exhibited high reliability (Cronbach's alpha = 0.938-0.965; ICC = 0.753-0.912), and confirmatory factor analysis indicated a good fit for a two-factor structure. ROC analysis revealed that the KVIQ-20 total and subscale scores showed statistically significant discriminative performance between the healthy and clinical groups (AUC = 0.644-0.768). In the known-groups analysis, the KVIQ-20 total and subscale scores significantly distinguished healthy individuals from individuals with rheumatoid arthritis (p ≤ 0.007), whereas the MIQ-3 total score did not reach significance in this distinction (p = 0.052). A high degree of convergent association was found between the MIQ-3 and KVIQ-20 (rs = 0.750; p < 0.001). According to the Kruskal-Wallis test results, no significant differences were found among individuals with rheumatoid arthritis in terms of MIQ-3 total score and KVIQ-20 total, visual, and kinesthetic subscale scores (p > 0.05). In conclusion, the Turkish versions of the MIQ-3 and KVIQ-20 are reliable measurement tools in individuals with rheumatoid arthritis; with stronger validity evidence for the KVIQ-20, the MIQ-3 assesses motor imagery at a global level, whereas the KVIQ-20 evaluates it together with its visual and kinesthetic subscales.
İskelet Kası Hücrelerinde Desmin'in Nükleer Protein Ortaklarının Araştırılması
(Sağlık Bilimleri Enstitüsü, 2026-08-13) inci deniz yılmaz; Tıbbi Biyoloji
Desmin is a type III intermediate filament protein involved in myofibrillar alignment and force transmission in muscle cells. Its presence in the nucleus suggests that it may participate in intranuclear processes in addition to its structural functions. This thesis aimed to characterize the nuclear interaction network of Desmin in skeletal muscle cells and investigate its potential association with chromatin organization. Human LHCN-M2 and mouse C2C12 cells were analyzed using RNA-sequencing data analysis, polymerase chain reaction, cellular fractionation, Western blotting, immunoprecipitation, and mass spectrometry. Because targeted approaches investigating the associations of Desmin with Nkx2.5 and SMYD1 yielded limited results, the study was redirected toward proteomic characterization of the nuclear Desmin interaction network. Desmin was confirmed to be present in the nuclear fraction and to co-precipitate with nuclear protein partners. In immunoprecipitation–mass spectrometry analysis, Desmin and Vimentin were enriched 47.5-fold and 159-fold, respectively. Candidate proteins were evaluated using a composite score integrating log₂FC, statistical significance, peptide-spectrum matches, unique peptide count, IP/IgG ratio, and evidence from independent datasets; TMPO, RANBP2, HNRNPU, NUP153, DDX5, and EEF1A1 were prioritized. Reciprocal IP–WB analyses demonstrated the co-precipitation of TMPO and DDX5 with Desmin, supporting their possible presence within the same protein complexes. The association of these candidates with the nuclear envelope, nuclear pore complex, and RNA metabolism suggests that Desmin may participate in intranuclear protein networks. RNase A treatment produced no statistically significant changes; however, EEF1A1 and HNRNPA2B1 showed decreasing trends consistent with possible RNA-mediated associations. Overall, this study characterized the nuclear interaction network of Desmin and provided evidence supporting its association with nuclear architecture, nucleocytoplasmic transport, and RNA-related protein networks.
AEROBİK VE DİRENÇ EGZERSİZLERİ UYGULANAN KLASİK FENİLKETONÜRİ HASTALARINDA EGZERSİZ ÖNCESİ VERİLEN FARKLI ÖĞÜN TÜRLERİNİN PLAZMA AMİNO ASİT DÜZEYLERİ VE METABOLİK KONTROL PARAMETRELERİ ÜZERİNE ETKİSİ
(Sağlık Bilimleri Enstitüsü, 2026-08-06) KALKAN DAMLA; Beslenme ve Diyetetik
Kalkan D. Effect of Different Meal Types Given Before Exercise on Plasma Amino Acid Levels and Metabolic Control Parameters in Classical Phenylketonuria Patients Undergoing Aerobic and Resistance Exercises. Hacettepe University, Graduate School of Health Sciences, Program of Nutrition and Dietetics, PhD Thesis, Ankara, 2026. In this single-center, randomised cross-over designed study, the nutritional status and physical activity levels of adult phenylketonuria (PKU) patients were evaluated in the first phase, and 10 adult classic PKU patients (50% male, 50% female) with a mean age of 27.7±5.0 years who agreed to participate in the intervention study were included. 10 adult classic PKU patients (50% male, 50% female) with an average age of 27.7±5.0 years were included. Patients received three different test meals (water, carbohydrate, and carbohydrate+protein) before aerobic and resistance exercises, and these meals were evaluated in a randomised crossover design to assess their acute effects on plasma amino acid levels (phenylalanine, tyrosine, branched-chain amino acids) as well as serum glucose, insulin, blood urea nitrogen (BUN), and creatinine levels. Each participant performed aerobic and resistance exercises on a total of six different days with three different test meals, with a seven-day wash-out period between the sessions. The test meals were given 10 minutes before the exercise. Plasma amino acid levels, as well as serum glucose, insulin, BUN, and creatinine levels, were evaluated before the standard breakfast (-120 min), at the 0th minute of exercise, and at 30, 60, 90, and 120 minutes post-exercise. The test meals administered before exercise significantly affected the time-dependent changes of some amino acids. It was determined that the levels of tyrosine and branched-chain amino acids were higher after the meal containing carbohydrates and protein, while plasma phenylalanine levels were not affected by the type of meal, type of exercise, or their interactions (p>0.05). While serum glucose and insulin levels varied depending on the meal content, exercise-related physiological changes were observed in BUN and creatinine levels. However, the type of exercise (aerobic or resistance) did not have an independent significant effect on plasma amino acid levels and metabolic control parameters (p>0.05). While the changes observed in the biochemical parameters evaluated in the study largely occurred over time, significant differences related to meal type were determined in some amino acids. In conclusion, short-term moderate-intensity aerobic and resistance exercises did not negatively affect metabolic control in patients with classic phenylketonuria. The combined application of carbohydrates and a phenylalanine-free amino acid mixture before exercise contributed to the preservation of certain amino acid responses without causing an increase in phenylalanine levels. These findings suggest that in planning pre-exercise nutrition strategies for individuals with phenylketonuria, the composition of the meal may be more decisive than the type of exercise.