Hacettepe Üniversitesi Açık Erişim Sistemi (HÜAES)
- HÜAES, Hacettepe Üniversitesi bünyesinde üretilen kitap, makale, tez, bildiri, rapor gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Communities in DSpace
Select a community to browse its collections.
- Ankara State Conservatory
- Directorates
- Faculty of Dentistry
- Faculty of Pharmacy
- Faculty of Letters
Recent Submissions
SODYUM GLUKOZ KOTRANSPORTER-2 İNHİBİTÖRLERİNİN ALZHEİMER HASTALIĞI BENZERİ MODELDE NLRP3 İNFLAMAZOMU ARACILI NÖROİNFLAMASYON ÜZERİNE ETKİSİ
(Sağlık Bilimleri Enstitüsü, 2026-09-25) Mercan Buse Esra; Farmakoloji
Neuroinflammation, particularly microglial activation and NLRP3 inflammasome-mediated inflammatory responses, is an important component of Alzheimer’s disease (AD) pathogenesis. In addition to their glucose-lowering effects, sodium-glucose cotransporter-2 (SGLT-2) inhibitors have been shown to exert anti-inflammatory effects, which may be partly associated with suppression of the NLRP3 inflammasome. However, the effects of SGLT-2 inhibitors on NLRP3 inflammasome-related inflammatory responses under AD-like conditions have not yet been fully elucidated. In this study, the effects of bexagliflozin, dapagliflozin, empagliflozin, ertugliflozin, and canagliflozin were evaluated in amyloid beta (Aβ)- and lipopolysaccharide (LPS)-induced BV2 microglial inflammation models using MTT, Griess, Western blot, and ELISA assays. In the Aβ model, bexagliflozin significantly reduced NLRP3, ASC, and caspase-1 protein levels as well as IL-1β and IL-18 levels, whereas dapagliflozin reduced NLRP3 and ASC protein levels and both cytokines. Ertugliflozin and canagliflozin showed more selective effects, while empagliflozin did not produce significant changes in the evaluated markers. In the LPS model, all five inhibitors significantly reduced NLRP3, ASC, IL-1β, and IL-18 levels, whereas caspase-1 was reduced only by bexagliflozin and empagliflozin. These findings support the further evaluation, particularly of bexagliflozin and dapagliflozin, in mechanistic and preclinical studies as potential pharmacological candidates targeting the NLRP3 axis in AH-associated neuroinflammation.
THE BALANCE OF POWER POLITICS IN THE EASTERN MEDITERRANEAN: EXPLAINING THE US APPROACH TOWARD TÜRKİYE AND GREECE
(Sosyal Bilimler Enstitüsü, 2026) EMRE ÖZER; Uluslararası İlişkiler
This thesis analyzes whether Greece has become an intra-alliance balancing actor in the United States policy toward Türkiye within the framework of deepening strategic relationship between the United States and Greece since 2016. The theoretical framework is based on neorealist balance of power theory and the alliance literature. In this study, intra-alliance balancing refers to a strategy to alter patterns of dependence, expand strategic options and influence leverage among allies with different interests and threat perceptions. The study uses qualitative document analysis to examine official U.S. strategy documents, defense agreements, legislation, congressional hearings, statements at the presidential and ministerial levels, military doctrines, and relevant secondary literature.
Tutuklama Kararlarında Gerekçe
(Sosyal Bilimler Enstitüsü, 2026) Berfin BOZDEMİR; Kamu Hukuku
This study examines the measure of detention, the most serious interference with the right to liberty and security of person in Turkish Criminal Procedure Law, from the perspective of the obligation to "provide justification." The fundamental problem of the thesis is that, despite being a constitutional and legal obligation, detention orders in judicial practice are frequently issued with "pre-printed justifications" lacking concrete facts, and this situation transforms detention from a protective measure into a tool of "pre-emptive punishment."
The first part of the study examines the legal nature of detention in light of the principles of the rule of law and the presumption of innocence. By emphasizing that detention is exceptional, temporary, and a "last resort" (ultima ratio), it is demonstrated that this measure can only be used to ensure the integrity of the trial. The second part focuses on the functions of a reasoned decisionof the arrest warrants. The functions of the justification—preventing arbitrariness on the part of the judge, ensuring that the decision is based on rational grounds, and most importantly, enabling the defense to effectively exercise its right to appeal—are analyzed. Furthermore, it has been argued that the judge's discussion of the evidence in the arrest warrant does not constitute "prejudgment," but rather a legal obligation.
In the third and main section of the thesis, the material and formal elements that must be present in an arrest warrant pursuant to Article 101/2 of the Code of Criminal Procedure are examined within the framework of strong suspicion of crime, the requirement of concrete evidence, grounds for arrest (suspicion of escape and tampering with evidence), catalog crimes, and proportionality criteria. In particular, the requirement of "explaining with concrete facts why judicial control would be insufficient," is evaluated in light of current Constitutional Court and ECHR jurisprudence.
In conclusion, the thesis argues that the arrest regime in the Turkish judicial system should be freed from its "automated" and "standardized" structure and transformed into an individualized, persuasive, and verifiable reasoned structure according to the specifics of each concrete case. It is suggested that, in order to prevent arrest from leading to a human rights crisis, priority should be given to judicial control measures, judicial personnel should be trained in this area, and decisions without justification should trigger compensation liability and recourse mechanisms.
DİJİTAL HİZMET SUNUMUNA İLİŞKİN MESAFELİ SÖZLEŞMELERDE AYIPLI İFA
(Sosyal Bilimler Enstitüsü, 2026-10-09) Şerife Yağmur Uzunoğlu; Özel Hukuk
The provision of digital services through distance contracts has fundamentally transformed the legal relationship between consumers and traders. Consumers enter into contractual relationships without the opportunity to inspect or test the subject matter of the contract beforehand, yet remain bound by its legal consequences. This has increased the need for effective legal mechanisms to protect consumers, particularly in cases of defective digital service performance.
This study examines the consumer’s remedies and right to claim damages arising from the defective performance of digital services under Turkish consumer law. Considering the distinctive characteristics of digital services, it analyses the conditions for exercising these remedies, their legal consequences, and the scope of liability for damages.
The research is conducted primarily within the framework of the Turkish Consumer Protection Law No. 6502 and the Turkish Code of Obligations No. 6098. It also adopts a comparative law approach by examining Directive (EU) 2019/770 on certain aspects concerning contracts for the supply of digital content and digital services. In this context, the adequacy of the Turkish legal framework in addressing the specific legal and technical features of digital services is evaluated, and the principal legal issues encountered in practice are identified.
The study concludes that the current legal framework requires further development to respond to the evolving digital economy and that harmonisation with Directive (EU) 2019/770 is necessary to strengthen consumer protection in Turkish law.
Ev İşçisi Kadınların İş-Yaşam Deneyimleri: Nitel Bir Çalışma
(Eğitim Bilimleri Enstitüsü, 2026-10-09) Melike Hacer ÖZPOLAT; Rehberlik ve Psikolojik Danışmanlık
This study aims to examine women domestic workers’ everyday work-life experiences, the psychosocial difficulties they encounter, and the psychological resilience resources and character strengths they draw on in coping with these difficulties, from a positive psychology perspective. The research is a qualitative study conducted with an interpretive phenomenological approach. The participants were 15 women domestic workers. Data were collected through semi-structured interviews and analyzed using thematic analysis. Four main themes were identified: the work cycle, perceptions of pre-work and current life, risk factors, and protective factors. The findings showed that the women started working out of economic necessity, continued to carry care and household responsibilities after work, and faced physical strain, social stigma, unfair treatment by employers, and the risk of sexual harassment. Domestic work also provided economic autonomy, self-confidence, and an expanded social circle. Family support, spirituality, satisfaction from doing the job well, and individual coping strategies emerged as resilience resources. In terms of character strengths, patterns that can be associated with the virtues of courage, humanity, and transcendence were observed. The results indicate that the experiences of women domestic workers should be evaluated not only in terms of the difficulties they face but also in terms of their resources and strengths.