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İlaç Salımı için Mitomisin C Baskılanmış Manyetik Partikül Gömülü Kriyojellerin Hazırlanması
(Fen Bilimleri Enstitüsü, 2020)Controlled drug release is a technique used for releasing the drug in the desired site of the body at the therapeutic dose. In drug release systems, administration of the drug given to the patient in appropriate doses to ... -
Dişi ve Erkek Farelerde Depresyonun Stres ve Optogenetik Modelinde MSS-Kökenli Nöroinflamasyonun İncelenmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2022)There is ample evidence for the role of inflammatory signaling pathways in depression. However, in these studies, depression was modeled either by bacterial endotoxins or by acute stress, usually studied only in male animals ... -
Demokrat Parti Dönemi Türkiye-Irak İlişkilerinde A.B.D. Etkisi (1950-1960)
(Atatürk İlkeleri ve İnkılap Tarihi Enstitüsü, 2022)This work has been prepared to understand the influence of the US, which became hegemon power after the Cold War started, on Turkey's alliance relations with Iraq during the Democratic Party period. The US encouraged states ... -
Centella Asıatıca Bitki Özütü ile Kaplı Gümüş Nanopartikül İçeren Polimer Liflerin Yara İyileştirici Etkisinin in Vitro ve in Vivo Araştırılması
(Fen Bilimleri Enstitüsü, 2021)In this study, we synthesized functional silver nanoparticles (AgNPs) from silver ions using the therapeutic plant extract of Centella asiatica (CA). The formation of AgNPs coated with CA functional groups (CA-AgNPs) is ... -
Silan Modifiye Halloysit/Poli(Maleik Anhidrit-Ard-Stiren) Kopolimer-İlaç Konjugatların Tasarımı, Sentezi ve Karakterizasyonu
(Fen Bilimleri Enstitüsü, 2022-02-03)In this study, the design, synthesis and characterization of poly(maleic anhydride-alt- styrene) (Poly(MA-alt-St) copolymer and polymer/clay nanocomposites in different ratios were made. Poly(maleic anhydride-alt-styrene ... -
Graftıng Of Polystyrene To Poly(Ethylenealt- Tetrafluoroethylene) (Etfe) Fılms By Controlled Raft Polymerızatıon In The Presence Of A Crosslınkıng Agent
(Fen Bilimleri Enstitüsü, 2022)Controlling the molecular weights and distributions of polymers is not possible in syntheses carried out by conventional Free Radical Polymerization (FRP). This hinders the widespread use of FRP techniques in the synthesis ... -
Deselülerize Miyokard-Elastomer Yamaların Hazırlanması ve In Vitro Performanslarının İncelenmesi
(Fen Bilimleri Enstitüsü, 2021)Heart failure is the final stage of most cardiovascular diseases, such as myocardial infarction. Unlike other tissues such as bone and skin, heart tissue does not have the ability to regenerate and repair itself. This ... -
Adenozin Tayinine Yönelik Optik Temelli Nanosensörlerin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2022-01)In this thesis, a novel measurement method is proposed to measure the level of adenosine nucleoside which is a significant molecule utilized as a direct or indirect indicator to detect diseases such as neurodegenerative ... -
Aptamer Temelli Afinite Kromatografisiyle Protein C Saflaştırılmasının Araştırılması
(Fen Bilimleri Enstitüsü, 2021-12-30)Protein C (PC) is a vitamin K-dependent plasma protein. Activated Protein C (APC) is a glycoprotein derived from protein C. It is formed by cleavage of an activation peptide by the thrombin-linked thrombomodulin (T-TM) ... -
Yüksek Sıcaklık Proseslerinin, Silisyum Tabanlı Fotodedektör Aygıt Performansına Etkilerinin İncelenmesi
(Fen Bilimleri Enstitüsü, 2021)The goal of this thesis work is to produce photodetectors in P-I-N form by silicon substrate and to investigate effect of thermal oxidation and doping high temperature microfabrication steps of manufacturing levels of these ... -
Nanotopografik Fiber Matrikslerin Doku İskelesi Olarak Üretimi ve İn-Vitro Etkinliklerinin İncelenmesi
(Fen Bilimleri Enstitüsü, 2022)This study was funded by Hacettepe University Scientific Research Projects Coordination Unit (BAP) graduate project entitled "Production Of Nanotopographic Fiber Matrices As Tissue Scaffold And Investigation Of Their ... -
Spermatogenezin Tasarlanmış Farklı Üç Boyutlu Fare Epididimal Beyaz Yağ Dokusu - Testis Kokültüründe Değerlendirilmesi
(Fen Bilimleri Enstitüsü, 2022)Gonadotoxic treatments in childhood cancer patients damage the testicular germ cells and microenvironment, causing 46% of the patients to become infertile. Air-liquid interphase (ALI) and U-plate (UP) techniques are ... -
M13mp18 İskele İpliğinden DNA Origami Nanodemetlerin Geliştirilmesi Ve İlaç Taşıyıcı Olarak Kullanımının İncelenmesi
(Fen Bilimleri Enstitüsü, 2022)Currently, in nanotechnology and biomedical field DNA nanotechnology is more and more used instead of conventional methods and important studies are carried out. Complementary base pairing of DNA has taken it to the next ... -
Konkanavalin A Baskılanmış Yüzey Plazmon Rezonans Temelli Biyosensörün Hazırlanması
(Fen Bilimleri Enstitüsü, 2022)Within the scope of this thesis, a Concanavalin A imprinted surface plasmon resonance (SPR) biosensor was prepared for the determination of Concanavalin A. At the beginning, the surface of the SPR biosensor chip was modified ... -
Gıda Örneklerindeki Benzil Penisilin Hassas Tayinine Yönelik Moleküler Baskılanmış Polimer Temelli Optik Sensörlerin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2021)Penicillin is one of the most commonly used beta antibiotics and has long been widely used in the treatment of various bacterial infections in humans, livestock, poultry and aquaculture. Therefore, the detection of these ... -
Synthesis and Characterization of SbSe Thin Films for Photovoltaic Applications
(Fen Bilimleri Enstitüsü, 2021)In this thesis study, synthesis and characterization of an alternative absorber, antimony selenide (Sb2Se3), layer for photovoltaic applications have been investigated. Synthesis of the Sb2Se3 thin films has been carried ... -
Trombosit Aktivasyonu İçin Alternatif Mekanik Yöntemlerin Belirlenmesi ve Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2021-12)Platelets are blood cells involved in clot formation, wound healing, and tissue regeneration. By enriching the blood plasma with various separation methods, platelet-rich plasma (PRP) is obtained. The effectiveness of PRP ... -
Pamuklu Kumaş Üzerinde Yıkanmış Kan Lekesinin Raman Spektroskopi ve Kemometri ile Tespiti
(Fen Bilimleri Enstitüsü, 2022)Bloodstains are abundant biological fluids that are encountered in crime scenes. Precise bloodstain detection on the “proof” has vitally importance for ongoing or post-commital stages. The criminal inclined to dispose the ... -
Poli(3-hidroksi bütirat)/Poli(bütilen adipat-ko-tereftalat)/İpek- Bazlı Tendon Doku İskeleleri: Karakterizasyon ve Tenojenik Aktivite
(Fen Bilimleri Enstitüsü, 2022-02)Tendon ruptures are frequently seen in tendons due to inflammation and lesions caused by factors such as mechanical stress accumulation, aging, genetic predisposition, and trauma. Tendon tissue engineering approaches are ... -
Fenilketonüri Hastalığının Erken Teşhisi ve Takibi için Disk Tabanlı Hasta Başı Tanı Sisteminin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2021-12)Phenylketonuria (PKU) is an autosomal recessive metabolic disease due to dysfunction of phenylalanine hydroxylase (PAH) enzyme, which converts phenylalanine (Phe) amino acid to tyrosine amino acid. Phe amino acid and ...
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