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Mikrotübül İnhibitörlerinin Kanser Hücrelerinde Tehlike-İlişkili Moleküler Desen Düzeylerine Etkisinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2020)Cancer cells are proliferate rapidly and uncontrolled. Chemotherapeutics such as vinorelbine and colchicine affect the cell cycle and DNA synthesis mechanism; they causes cells to be kept in the G2 / M phase by preventing ... -
Pankreas Kanserinde MUC1, MUC4, MUC16 Molekülleri ile Treg Hücreleri ve Epitelyal-Mezenkimal Transizyon Arasındaki İlişki
(Kanser Enstitüsü, 2020-08-14)Pancreatic cancer has a poor prognosis due to its increased invasion and metastasis capacity. Transmembrane mucins normally have as their functions to protect the epithelial tissues but their expression level is has been ... -
Farklı Aktivasyon Basamaklarına İlerletilen Yardımcı T Hücrelerinde Adezyon ve Migrasyon Mekanizmalarının İncelenmesi
(Kanser Enstitüsü, 2020)When different analog T lymphocyte profiles are examined in cancer and chronic infections, these cells can be divided into two subgroups with functional and dysfunctiononal characterization. Naive T lymphocytes which are ... -
The Association Between Body Mass Index and Immunohistochemical Subtypes in Breast Cancer
(Elsevier, 2017)Background:Body mass index (BMI) is defined as a poor prognostic factor in patients with breast cancer(BC). However, there are controversial results regarding the various effects of BMI on BC, hence the exactpathophysiology ... -
Targeted Therapies in Gastric Cancer and Future Perspectives
(Baishideng Publishing Group Inc, 2016)Advanced gastric cancer (AGC) is associated with a high mortality rate and, despite multiple new chemotherapy options, the survival rates of patients with AGC remains poor. After the discovery of targeted therapies, research ... -
Tamoxifen-Induced Tissue Factor Pathway Inhibitor Reduction: A Clue for an Acquired Thrombophilic State?
(Oxford Univ Press, 2004)Background: Current understanding of hemostatic systems enables us to better explore the enigmatic pathobiology of tamoxifen (TAM)-induced thrombotic diathesis. We have therefore aimed to assess the hemostatic changes in ... -
Successful Treatment of Intracaval and Atrial Extension of Wilms' Tumour by Chemotherapy
(British Med Journal Publ Group, 1996)A patient presenting with advanced Wilms' tumour was diagnosed as having inferior vena cava involvement with tumour thrombus extending up to the right atrium, and was treated with preoperative chemotherapy (vincristine, ... -
Stereotactic Re-Irradiation For Recurrent Or Second Primary Head-And-Neck Cancer
(The Official Journal of Turkish Society for Radiation Oncology, 2018)Local recurrence after definitive radiotherapy for advanced head-and-neck cancer is observed in 30%– 60% of the patients. Surgical resection is possible in only about 25% of the cases. Re-irradiation for local recurrence ... -
Smooth Muscle Cells Isolated from Thoracic Aortic Aneurysms Exhibit Increased Genomic Damage, but Similar Tendency for Apoptosis
(Mary Ann Liebert Inc, 2012)Aortic aneurysms (AA) are characterized by structural deterioration leading to progressive dilation. During the development of AA, two key structural changes are pronounced, one being degradation of extracellular matrix ... -
Smoking Habits of Relatives of Patients with Cancer: Cancer Diagnosis in the Family is an Important Teachable Moment for Smoking Cessation
(Asian Pacific Organization Cancer Prevention, 2013)Background: In this study we aimed to determine the rate and habitual patterns of smoking, intentions of cessation, dependence levels and sociodemographic characteristics of relatives of patients with a diagnosis of cancer. ... -
Single Institution Experience on Cancer Among Adolescents 15-19 Years of Age
(Turkish J Pediatrics, 2017)Adolescent cancers differ from other age groups in terms of cancer types, treatment and outcome. We aimed to present our institutional data on survival of certain types of cancer in adolescents. Hospital files were ... -
Serum 25-Hydroxy Vitamin D Status Is Not Related To Osteopenia/Osteoporosis Risk in Colorectal Cancer Survivors
(Asian Pacific Organization Cancer Prevention, 2014)Background: The incidence of colorectal cancer increases with vitamin D deficiency as shown in recently published studies. In addition, prospective investigations have indicated that low vitamin D levels may be associated ... -
The Relationship of Agmatine Deficiency with the Lung Cancer
(Akad Doktorlar Yayınevi, 2016)The polyamines are essential for rapidly growing cells. Polyamines is synthesized by two reactions which begin from arginine. The aim of this study is to examine the serum levels of the enzymes located in the putrescine ... -
Transfection of Myeloid Leukaemia Cell Lines Is Distinctively Regulated By Fibronectin Substratum
(Springer, 2009)Gene transfer into haematopoietic cells is a challenging approach. The extracellular matrix component fibronectin has been known to modulate the cell cycle dynamics, viability and differentiation of leukaemia cells. Thus, ... -
Ubiquitination And Regulation Of Aurka Identifies A Hypoxia-Independent E3 Ligase Activity Of Vhl
(Nature Publishing Group, 2017)The hypoxia-regulated tumor-suppressor von Hippel-Lindau (VHL) is an E3 ligase that recognizes its substrates as part of an oxygen-dependent prolyl hydroxylase (PHD) reaction, with hypoxia-inducible factor α (HIFα) being ... -
Vaccination Attitudes Among Patients With Cancer Receiving Chemotherapy
(Akad Doktorlar Yayınevi, 2016)Immunization against vaccine preventable diseases is an essential but mostly overlooked issue in oncology practice. We aimed to investigate the utilization of adult immunization recommendations and the perception of the ... -
Long-Term Survival of Patients with Cll After Allogeneic Transplantation: A Report from the European Society for Blood and Marrow Transplantation
(Macmillan Publishers Limited, 2017)Even with the availability of targeted drugs, allogeneic hematopoietic cell transplantation (allo-HCT) is the only therapy with curative potential for patients with CLL. Cure can be assessed by comparing long-term survival ... -
Psoriasiste Lipocalin 2 Spesifik Reseptörünün Immünohistokimyasal Olarak Saptanması
(2015)Amaç: Serum Lipokalin 2 (LCN2) seviyelerinin psoriasiste artmış inflamasyon için bir genel belirteç olduğu bilinmektedir. Bu çalışmada, LCN2’nin psoriatik lezyonlardaki reseptör düzeyini araştırmayı amaçladık. Yöntemler: ... -
Immunohistochemical Expression of Insulin-Like Growth Factor-1, Transforming Growth Factor-Beta1, and Vascular Endothelial Growth Factor In Parathyroid Adenoma and Hyperplasia
(Medknow Publications & Media Pvt Ltd, 2014)Background: Insulin-like growth factor (IGF), transforming growth factor-beta1 (TGF-beta 1), and vascular endothelial growth factor (VEGF) are commonly studied growth factors, but little data are available on the ... -
Good Outcomes Of Patients With Stage Ib Endometrial Cancer With Surgery Alone
(Asian Pacific Organization Cancer Prevention, 2014)Background: Most patients with endometrial cancer have stage I disease. Adjuvant therapy in stage IB (formerly IC) endometrial cancer is controversial, treatment options including observation or brachytherapy/radiotherapy ...
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