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Hacettepe Üniversitesi Onkoloji Hastanesinde Yatmakta Olan Hastalara Bakım Verenlerin Sosyodemografik Özelliklerinin ve Yaşam Kalitelerinin, Hastaların Yaşam Kalitesi Üzerine Etkisi
(Kanser Enstitüsü, 2022)Güner Üliç. P., The Effects of Sociodemographic Characteristics and Quality Of Life of Caregivers on Quality of Life of Inpatient Cancer Patients in Hacettepe University Oncology Hospital, Hacettepe University Graduate ... -
İNSAN MAKROFAJLARINDA NİTRİK OKSİT SENTAZ 2 (NOS2) İFADE VE AKTİVİTESİNİN BAZAL BENZERİ MEME KANSERİ HÜCRELERİNDEN ÜRETİLEN FAKTÖRLER VARLIĞINDA İNCELENMESİ
(Sağlık Bilimleri Enstitüsü, 2022)Macrophages are the leading cells of innate immunity in the immune response against pathogens and are involved in the regulation of adaptive immune responses. Macrophages with microbicidal properties promote the proinflammatory ... -
Akciğer Kanser Hücrelerinden Salınan Eksozomların Makrofaj Polarizasyonuna ve Fonksiyonlarına Etkisinin Araştırılması
(Kanser Enstitüsü, 2021)Lung cancer has the highest mortality rate in both men and women worldwide. With our developing technology and knowledge, the research of methods in cancer targeted treatments have turned to target such as tumor microenvironment, ... -
The Role of Regnase-1 Protein in Sculpting of Tumor Microenvironment
(Kanser Enstitüsü, 2021)The tumor microenvironment (TME) contains cancer-associated fibroblasts (CAFs) and their tumor-supportive role helps to build an environment in favor of cancer cell progression. Recent researches have revealed that targeting ... -
HER2 EKSPRESYONU OLAN MEME KANSERİ HÜCRELERİNDE ÖKARYOTİK ELONGASYON FAKTÖR-2 KİNAZ (eEF2K) AKTİVASYONUNUN ROLÜ
(Kanser Enstitüsü, 2021-06-22)Continuous activation of HER2 leads to the deregulation of various biological responses such as cell proliferation, survival, and migration, and tumor growth. eEF2K is a protein kinase involved in the regulation of protein ... -
Hipoksinin Anti-Tümor İmmün Yanıt Üzerine Etkisinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2021)Inhibition of tumor angiogenesis has been extensively utilized in the treatment of metastatic colorectal cancer and renal cell carcinoma. Complete disruption of tumor angiogenesis results in hypoxia which promotes tumor ... -
Β-Catenın N-Terminal Bölge Değişikliklerinin Neoplastik Süreçlerdeki Rolünün Araştırılması
(Kanser Enstitüsü, 2021)Uzun, S, Investigation of The Role of β-catenin N-terminal Domain Alterations in Neoplastic Processes, Hacettepe University Graduate School of Health Sciences Tumor Biology and Immunology Program Doctor of Philosophy ... -
Tüm Beden Işınlamalarında Farklı Tedavi Planlama Tekniklerinin Dozimetrik Olarak Karşılaştırılması
(Kanser Enstitüsü, 2021-02-10)The purpose of Total Body Irradiation (TBI) in radiotherapy is to suppress the immune system of the patient by destroying bone marrow cells, prepare the host for bone marrow transplantation and enhance the antitumor effect. ... -
Stereotaktik Radyocerrahi ve Stereotaktik Beden Radyoterapisi Uygulamalarında Manyetik Rezonans Görüntüleme Tabanlı Tedavi Planlama Sisteminin Kullanılabilirliği
(Kanser Enstitüsü, 2021-02-05)In this study, feasibility of Magnetic Resonance Imaging (MRI) based treatment planning system instead of computed tomography (CT) in SRC and SBRT was evaluated. Three different scenarios were created for density and ... -
Cyberknife® ve Varian RapidArc® TrilogyTM Cihazında Üç Boyutlu Uzaysal Fraksiyone Grid Terapi Doz Karakteristiklerinin Karşılaştırılması
(Kanser Enstitüsü, 2020-12). Lattice therapy is an innovative method to increase the effectiveness of radiotherapy by delivering a high dose to the target volume irradiated through small spaces in one or more fractions.In this study, we investigated ... -
Mikrotübül İnhibitörlerinin Kanser Hücrelerinde Tehlike-İlişkili Moleküler Desen Düzeylerine Etkisinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2020)Cancer cells are proliferate rapidly and uncontrolled. Chemotherapeutics such as vinorelbine and colchicine affect the cell cycle and DNA synthesis mechanism; they causes cells to be kept in the G2 / M phase by preventing ... -
Pankreas Kanserinde MUC1, MUC4, MUC16 Molekülleri ile Treg Hücreleri ve Epitelyal-Mezenkimal Transizyon Arasındaki İlişki
(Kanser Enstitüsü, 2020-08-14)Pancreatic cancer has a poor prognosis due to its increased invasion and metastasis capacity. Transmembrane mucins normally have as their functions to protect the epithelial tissues but their expression level is has been ... -
Farklı Aktivasyon Basamaklarına İlerletilen Yardımcı T Hücrelerinde Adezyon ve Migrasyon Mekanizmalarının İncelenmesi
(Kanser Enstitüsü, 2020)When different analog T lymphocyte profiles are examined in cancer and chronic infections, these cells can be divided into two subgroups with functional and dysfunctiononal characterization. Naive T lymphocytes which are ... -
The Association Between Body Mass Index and Immunohistochemical Subtypes in Breast Cancer
(Elsevier, 2017)Background:Body mass index (BMI) is defined as a poor prognostic factor in patients with breast cancer(BC). However, there are controversial results regarding the various effects of BMI on BC, hence the exactpathophysiology ... -
Targeted Therapies in Gastric Cancer and Future Perspectives
(Baishideng Publishing Group Inc, 2016)Advanced gastric cancer (AGC) is associated with a high mortality rate and, despite multiple new chemotherapy options, the survival rates of patients with AGC remains poor. After the discovery of targeted therapies, research ... -
Tamoxifen-Induced Tissue Factor Pathway Inhibitor Reduction: A Clue for an Acquired Thrombophilic State?
(Oxford Univ Press, 2004)Background: Current understanding of hemostatic systems enables us to better explore the enigmatic pathobiology of tamoxifen (TAM)-induced thrombotic diathesis. We have therefore aimed to assess the hemostatic changes in ... -
Successful Treatment of Intracaval and Atrial Extension of Wilms' Tumour by Chemotherapy
(British Med Journal Publ Group, 1996)A patient presenting with advanced Wilms' tumour was diagnosed as having inferior vena cava involvement with tumour thrombus extending up to the right atrium, and was treated with preoperative chemotherapy (vincristine, ... -
Stereotactic Re-Irradiation For Recurrent Or Second Primary Head-And-Neck Cancer
(The Official Journal of Turkish Society for Radiation Oncology, 2018)Local recurrence after definitive radiotherapy for advanced head-and-neck cancer is observed in 30%– 60% of the patients. Surgical resection is possible in only about 25% of the cases. Re-irradiation for local recurrence ... -
Smooth Muscle Cells Isolated from Thoracic Aortic Aneurysms Exhibit Increased Genomic Damage, but Similar Tendency for Apoptosis
(Mary Ann Liebert, Inc, 2012)Aortic aneurysms (AA) are characterized by structural deterioration leading to progressive dilation. During the development of AA, two key structural changes are pronounced, one being degradation of extracellular matrix ... -
Smoking Habits of Relatives of Patients with Cancer: Cancer Diagnosis in the Family is an Important Teachable Moment for Smoking Cessation
(Asian Pacific Organization Cancer Prevention, 2013)Background: In this study we aimed to determine the rate and habitual patterns of smoking, intentions of cessation, dependence levels and sociodemographic characteristics of relatives of patients with a diagnosis of cancer. ...
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