Cortical spreading depression (CSD) is the likely cause of the migraine aura. CSD causes a signaling pathway between stressed neurons and trigeminal afferents via transient opening of neuronal Pannexin-1 (Panx1) mega-channels ...

Neuroinflammation has been shown to be involved in pathological conditions like cortical spreading depression, seizures and ischemia. Its involvement in physiological processes like neurogenesis, learning and memory has ...