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dc.contributor.authorArsava, Ethem M.
dc.contributor.authorBas, Demet F.
dc.contributor.authorAtalar, Enver
dc.contributor.authorHas, Arzu C.
dc.contributor.authorOguz, Kader K.
dc.contributor.authorTopcuoglu, Mehmet A.
dc.date.accessioned2019-12-10T11:31:37Z
dc.date.available2019-12-10T11:31:37Z
dc.date.issued2015
dc.identifier.issn0039-2499
dc.identifier.urihttps://doi.org/10.1161/STROKEAHA.114.006396
dc.identifier.urihttp://hdl.handle.net/11655/15934
dc.description.abstractBackground and Purpose-The widespread use of ambulatory cardiac monitoring has not only increased the detection of high-risk arrhythmias like persistent and paroxysmal atrial fibrillation (AF), but also made it possible to identify other aberrations such as short-lasting (<30 seconds) irregular runs of supraventricular tachycardia. Ischemic stroke phenotype might be helpful in understanding whether these nonsustained episodes play a similar role in stroke pathophysiology like their persistent and paroxysmal counterparts. Methods-In a consecutive series of patients with ischemic stroke, we retrospectively determined clinical and imaging features associated with nonsustained AF (n=126), defined as <30-second-lasting supraventricular tachyarrhythmias with irregular RR interval on 24-hour Holter monitoring, and compared them to patients with persistent/paroxysmal AF (n=239) and no AF (n=246). Results-Patients with persistent/paroxysmal AF significantly differed from patients with nonsustained AF by a higher prevalence of female sex (odds ratio [95% confidence interval], 1.8 [1.1-2.9]), coronary artery disease (1.9 [1.1-3.0]), and embolic imaging features (2.7 [1.1-6.5]), and lower frequency of smoking (0.4 [0.2-0.8]) and hyperlipidemia (0.5 [0.3-0.8]). In contrast, patients with no AF were younger (0.5 [0.4-0.6] per decade) and more likely to be male (1.7 [1.0-2.8]) in comparison with nonsustained AF population. The prevalence of nonsustained AF was similar among cryptogenic and noncryptogenic stroke patients (32% versus 29%). Voxel-wise comparison of lesion probability maps revealed no significant difference between cryptogenic stroke patients with and without nonsustained AF. Conclusions-Clinical features of patients with nonsustained AF exhibited an intermediary phenotype in between patients with persistent/paroxysmal AF and no AF. Furthermore, imaging features did not entirely resemble patterns observed in patients with longer durations of AF.
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.isversionof10.1161/STROKEAHA.114.006396
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNeurosciences & Neurology
dc.subjectCardiovascular System & Cardiology
dc.titleIschemic Stroke Phenotype in Patients with Nonsustained Atrial Fibrillation
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalStroke
dc.contributor.departmentRadyoloji
dc.identifier.volume46
dc.identifier.issue3
dc.identifier.startpage634
dc.identifier.endpage+
dc.indexingWoS
dc.indexingScopus


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