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dc.contributor.authorGurcan, Oktay
dc.contributor.authorGurcat, Ahmet Gurhan
dc.contributor.authorKazanci, Atilla
dc.contributor.authorSenturk, Salim
dc.contributor.authorBodur, Ebru
dc.contributor.authorKaraca, Ebru Umay
dc.contributor.authorTurkoglu, Omer Faruk
dc.contributor.authorBavbek, Murad
dc.date.accessioned2019-12-12T06:24:20Z
dc.date.available2019-12-12T06:24:20Z
dc.date.issued2017
dc.identifier.issn1019-5149
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.15747-15.2
dc.identifier.urihttp://hdl.handle.net/11655/16152
dc.description.abstractAIM: Spinal cord injury (SCI) is a devastating condition of the central nervous system. There is no proven therapeutic agent for the treatment of this complex disorder. Asiatic acid (AA) has been used as an anti-inflammatory and anti-oxidant agent in Eastern countries for many years. The aim of this study was to investigate the effectiveness of AA on the treatment of traumatic SCI in rats. MATERIAL and METHODS: Thirty-two adult male Sprague-Dawley rats were divided into 4 groups as laminectomy, laminectomy+trauma, vehicle, and M treatment groups. SCI was created by the modified Allen's weight-drop technique. After the injury, the levels of pro-inflammatory cytokines (IL-6, IL-beta, TNF-alpha) and lipid peroxidation products (MDA) were measured. Tarlov functional recovery scores were also determined for each rat. The One-way ANOVA test was used for the analysis of difference between 4 experimental groups and the groups were compared individually by Tukey-LSD post hoc analysis test (p=0.001). RESULTS: AA administration just after SCI attenuated the levels of lipid peroxidation products (MDA) and pro-inflammatory cytokines (TNF-alpha,IL1 beta). It also increased the Tarlov functional recovery scores of the rats. CONCLUSION: AA administration could attenuate a number of deleterious reactions after traumatic SCI. Further studies are needed to elucidate the pathways of neuroprotective effects of AA after spinal trauma.
dc.language.isoen
dc.publisherTurkish Neurosurgical Soc
dc.relation.isversionof10.5137/1019-5149.JTN.15747-15.2
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNeurosciences & Neurology
dc.subjectSurgery
dc.titleEffect of Asiatic Acid on The Treatment of Spinal Cord Injury: an Experimental Study in Rats
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalTurkish Neurosurgery
dc.contributor.departmentTıbbi Biyokimya
dc.identifier.volume27
dc.identifier.issue2
dc.identifier.startpage259
dc.identifier.endpage264
dc.indexingWoS
dc.indexingScopus


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