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dc.contributor.authorDogan, A. Umran
dc.contributor.authorBaris, Y. Izzettin
dc.contributor.authorDogan, Meral
dc.contributor.authorEmri, Salih
dc.contributor.authorSteele, Ian
dc.contributor.authorElmishad, Amira G.
dc.contributor.authorCarbone, Michele
dc.date.accessioned2019-12-13T10:57:52Z
dc.date.available2019-12-13T10:57:52Z
dc.date.issued2006
dc.identifier.issn0008-5472
dc.identifier.urihttps://doi.org/10.1158/0008-5472.CAN-05-4642
dc.identifier.urihttp://hdl.handle.net/11655/18921
dc.description.abstractMalignant mesothelioma in the western world is often associated with asbestos exposure. It is a relatively rare cancer that causes similar to 2,500 deaths yearly in the United States and 1,000 deaths yearly in the United Kingdom. In contrast, among people born in the Cappadocian (Turkey) villages of Tuzkoy, Karain, and "Old" Sarihidir, similar to 50% of deaths are caused by malignant mesothelioma. This epidemic has been attributed to erionite exposure, a type of fibrous zeolite mineral commonly found in this area of Turkey. In these three villages, malignant mesothelioma occurs in certain houses but not in others. The hypothesis was that a unique and more carcinogenic erionite was present in certain houses and caused malignant mesothelioma. We determined the X-ray diffraction pattern and the crystal structure of erionite from malignant mesothelioma villages and compared the results with the erionite samples from nearby non-malignant mesothelioma villages and from the United States. We found the same type of erionite in Cappadocian villages, with or without a malignant mesothelioma epidemic, in households with high or no incidence of malignant mesothelioma and in the United States. Pedigree studies of the three malignant mesothelioma villages showed that malignant mesothelioma was prevalent in certain families but not in others. When high-risk malignant mesothelioma family members married into families with no history of it, malignant mesothelioma appeared in the descendants. Genetically predisposed family members born and raised outside the malignant mesothelioma villages did not seem to develop malignant mesothelioma. In summary, pedigree and mineralogical studies indicate that the malignant mesothelioma epidemic is caused by erionite exposure in genetically predisposed individuals. This is the first time that genetics is shown to influence mineral fiber carcinogenesis.
dc.language.isoen
dc.publisherAmer Assoc Cancer Research
dc.relation.isversionof10.1158/0008-5472.CAN-05-4642
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOncology
dc.titleGenetic Predisposition To Fiber Carcinogenesis Causes A Mesothelioma Epidemic In Turkey
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalCancer Research
dc.contributor.departmentJeoloji Mühendisliği
dc.identifier.volume66
dc.identifier.issue10
dc.identifier.startpage5063
dc.identifier.endpage5068
dc.indexingWoS
dc.indexingScopus


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