Show simple item record

dc.contributor.authorTok, Tugba Taskin
dc.contributor.authorOzasik, Ozgun
dc.contributor.authorSarigol, Deniz
dc.contributor.authorBaran, Ayse Uzgoren
dc.date.accessioned2019-12-13T11:04:54Z
dc.date.available2019-12-13T11:04:54Z
dc.date.issued2015
dc.identifier.issn1300-0527
dc.identifier.urihttps://doi.org/10.3906/kim-1401-91
dc.identifier.urihttp://hdl.handle.net/11655/18976
dc.description.abstractA series of N-acylhydrazone derivatives (2a-2p) containing 6-methoxy-naphthalene and acylhydrazone moieties were synthesized in good yield using microwave irradiation and developed as potential COX-2 inhibitors. Furthermore, the interactions between COX-2 and the compounds were examined in detail by molecular modeling studies such as structure activity relationship and molecular docking performed using Gaussian 09 and Discovery Studio 3.5. As a result, it was found that N-acylhydrazone compounds displayed a different mechanism than SC-558 as COX-2 inhibitor by binding to different active sites of the protein, COX-2. Compound 2c would be a good COX-2 inhibitor candidate for preclinical studies.
dc.language.isoen
dc.publisherScientific Technical Research Council Turkey-Tubitak
dc.relation.isversionof10.3906/kim-1401-91
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChemistry
dc.subjectEngineering
dc.titleSynthesis and Molecular Modeling Studies of Naproxen-Based Acyl Hydrazone Derivatives
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalTurkish Journal Of Chemistry
dc.contributor.departmentKimya Mühendisliği
dc.identifier.volume39
dc.identifier.issue1
dc.identifier.startpage64
dc.identifier.endpage83
dc.indexingWoS
dc.indexingScopus


Files in this item

This item appears in the following Collection(s)

Show simple item record