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dc.contributor.authorSahin Yaglioglu, Ayse
dc.contributor.authorSenoz, Hulya
dc.date.accessioned2019-12-13T11:04:58Z
dc.date.available2019-12-13T11:04:58Z
dc.date.issued2017
dc.identifier.issn1300-0527
dc.identifier.urihttps://doi.org/10.3906/kim-1612-42
dc.identifier.urihttp://hdl.handle.net/11655/18982
dc.description.abstractNovel 1-substituted 3-(p-isopropylphenyl)-5-phenylformazans (3a-g) were synthesized and characterized by elemental analysis, H-1 NMR, and FT-IR techniques and UV-visible spectroscopy. Antiproliferative activities of 3a-g against HeLa and C6 cells were determined using the BrdU cell proliferation ELISA assay. 5-Florouracil was used as the positive control. The effects of substituents (-H, -CH3, and A) and their positions (ortho, meta, and para) on the antiproliferative activities were evaluated. The results of the assay indicate that I substituent exhibited higher activity against the cells at the meta and para positions than -CH3 and -H substituents. 3a-g exhibited both high antiproliferative activities against C6 cells and noncytotoxicity. 3a-g may be anticancer drug candidates.
dc.language.isoen
dc.publisherScientific Technical Research Council Turkey-Tubitak
dc.relation.isversionof10.3906/kim-1612-42
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChemistry
dc.subjectEngineering
dc.titleSynthesis of Novel 5-Substituted Phenyl-3-(P-Isopropylpheny1)-1-Phenylformazan and Their Biological Activities
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalTurkish Journal Of Chemistry
dc.contributor.departmentKimya Mühendisliği
dc.identifier.volume41
dc.identifier.issue6
dc.identifier.startpage883
dc.identifier.endpage891
dc.indexingWoS


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