Show simple item record

dc.contributor.authorManey, Pooja
dc.contributor.authorEmecen, Pinar
dc.contributor.authorMills, John S.
dc.contributor.authorWalters, John D.
dc.date.accessioned2019-12-16T06:53:34Z
dc.date.available2019-12-16T06:53:34Z
dc.date.issued2009
dc.identifier.issn0022-3492
dc.identifier.urihttps://doi.org/10.1902/jop.2009.080225
dc.identifier.urihttp://hdl.handle.net/11655/19129
dc.description.abstractBackground: Neutrophil formylpeptide receptors (FPRs) play an important role in bacterial recognition and chemotaxis. Defective FPR1 expression and impaired polymorphonuclear leukocyte chemotaxis toward bacterial formylpeptides are associated with aggressive periodontitis (AgP). The objective of this study was to determine whether single nucleotide polymorphisms (SNPs) in FPR1 are associated with AgP. Methods: Genomic DNA was isolated from blood samples obtained from African Americans (30 subjects with AgP and 33 healthy controls) and Turks (75 subjects with AgP and 63 healthy controls). A highly polymorphic fragment of the FPR1 gene was amplified by polymerase chain reaction and sequenced for analysis of SNPs. Results: Five previously identified SNPs were detected in African Americans, whereas six were detected in Turkish subjects. The frequency of synonymous SNP c.348T>C was significantly higher in African Americans with AgP than in controls (P=0.029). The 348T allele was significantly associated with AgP (P= 0.010). Seven of the subjects with AgP, but none of the controls, were homozygous for 348T. FPR1 haplotypes 348T.568A, 348T.576T, and 348T.568A.576T were significantly increased in African Americans with AgP (P <0.02). The Turkish population did not exhibit significant differences in FPR1 SNP frequencies between subjects with AgP and controls. Conclusions: FPR1 SNP c.348T>C is associated with AgP in African Americans. Individuals who are homozygous for 348T may have an increased risk for developing this disorder. J Periodontol 2009;80:492-498.
dc.language.isoen
dc.publisherWiley
dc.relation.isversionof10.1902/jop.2009.080225
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDentistry, Oral Surgery & Medicine
dc.titleNeutrophil Formylpeptide Receptor Single Nucleotide Polymorphism 348T > C In Aggressive Periodontitis
dc.typeinfo:eu-repo/semantics/article
dc.relation.journalJournal Of Periodontology
dc.contributor.departmentPeriodontoloji
dc.identifier.volume80
dc.identifier.issue3
dc.identifier.startpage492
dc.identifier.endpage498
dc.indexingWoS


Files in this item

This item appears in the following Collection(s)

Show simple item record