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dc.contributor.authorBakhshpour, Monireh
dc.contributor.authorYavuz, Handan
dc.contributor.authorDenizli, Adil
dc.date.accessioned2019-12-16T09:18:44Z
dc.date.available2019-12-16T09:18:44Z
dc.date.issued2018
dc.identifier.issn2169-1401
dc.identifier.urihttps://doi.org/10.1080/21691401.2018.1439840
dc.identifier.urihttp://hdl.handle.net/11655/19609
dc.description.abstractMolecular imprinting technique was used for the preparation of antibiotic and anti-neoplastic chemotherapy drug (mitomycin C) imprinted cryogel membranes (MMC-ICM). The membranes were synthezied by using metal ion coordination interactions with N-methacryloyl-(l)-histidine methyl ester (MAH) functional monomer and template molecules (i.e. MMC). The 2-hydroxyethyl methacrylate (HEMA) monomer and methylene bisacrylamide (MBAAm) crosslinker were used for the preparation of mitomycin C imprinted cryogel membranes by radical suspension polymerization technique. The imprinted cryogel membranes were characterized by scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET), Fourier transform infrared spectroscopy-attenuated total reflectance (FTIR-ATR) and swelling degree measurements. Cytotoxicity of MMC-ICMs was investigated using mouse fibroblast cell line L929. Time-dependent release of MMC was demonstrated within 150h from cryogel membranes. Cryogels demonstrated very high MMC loading efficiency (70-80%) and sustained MMC release over hours.
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.isversionof10.1080/21691401.2018.1439840
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiotechnology & Applied Microbiology
dc.subjectEngineering
dc.subjectMaterials Science
dc.titleControlled Release Of Mitomycin C From Phemah-Cu(Ii) Cryogel Membranes
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalArtificial Cells Nanomedicine And Biotechnology
dc.contributor.departmentKimya
dc.identifier.volume46
dc.identifier.startpageS946
dc.identifier.endpageS954
dc.indexingWoS
dc.indexingScopus


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