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dc.contributor.authorOrhan, İlkay Erdoğan
dc.contributor.authorGulyurdu, Fulya
dc.contributor.authorAkkol, Esra Kupeli
dc.contributor.authorSenol, Fatma Sezer
dc.contributor.authorAnul, Serap Arabaci
dc.contributor.authorTatli, Iffet Irem
dc.date.accessioned2019-12-16T10:09:31Z
dc.date.available2019-12-16T10:09:31Z
dc.date.issued2016
dc.identifier.issn1388-0209
dc.identifier.urihttps://doi.org/10.1080/13880209.2016.1177092
dc.identifier.urihttp://hdl.handle.net/11655/19923
dc.description.abstractContext:Xeranthemum annuum L. (Asteraceae) (XA) is an ornamental and medicinal species with limited bioactivity and phytochemical data.Objective: Identification of anticholinesterase, antioxidant, anti-inflammatory and analgesic effects of the flower and root-stem (R-S) extracts of XA.Materials and methods: Anticholinesterase (at 100gmL(-1)) and antioxidant (at 1000gmL(-1)) effects of various extracts were evaluated via microtiter assays, while anti-inflammatory and analgesic effects of the R-S extracts were tested using carrageenan-induced hind paw oedema (100 and 200mg kg(-1)) and p-benzoquinone (PBQ) writhing models (200mg kg(-1)) in male Swiss albino mice. The R-S ethanol extract of XA was subjected to isolation studies using conventional chromatographic methods.Results: Most of the extracts showed inhibition over 85% against butyrylcholinesterase and no inhibition towards acetylcholinesterase. The flower chloroform and the R-S ethyl acetate extracts were most effective (97.850.94% and 96.89 +/- 1.09%, respectively). The R-S ethanol extract displayed a remarkable scavenging activity against DPPH (77.33 +/- 1.99%) and in FRAP assay, while the hexane extract of the R-S parts possessed the highest metal-chelating capacity (72.79 +/- 0.33%). The chloroform extract of the R-S caused a significant analgesic effect (24.4%) in PBQ writhing model. No anti-inflammatory effect was observed. Isolation of zierin and zierin xyloside, which were inactive in anticholinesterase assays, was achieved from the R-S ethanol extract.Discussion and conclusion: This is the first report of anticholinesterase, antioxidant, analgesic and anti-inflammatory activities and isolation of zierin and zierin xyloside from XA. Therefore, XA seems to contain antioxidant and BChE-inhibiting compounds.
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.isversionof10.1080/13880209.2016.1177092
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPlant Sciences
dc.subjectMedical Laboratory Technology
dc.subjectPharmacology & Pharmacy
dc.titleAnticholinesterase, Antioxidant, Analgesic and Anti-Inflammatory Activity Assessment of Xeranthemum Annuum L. And Isolation of Two Cyanogenic Compounds
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalPharmaceutical Biology
dc.contributor.departmentFarmasötik Botanik
dc.identifier.volume54
dc.identifier.issue11
dc.identifier.startpage2643
dc.identifier.endpage2651
dc.indexingWoS


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