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dc.contributor.authorSipahi, Hande
dc.contributor.authorGirgin, Gozde
dc.contributor.authorInanici, Fatma
dc.contributor.authorAriogul, Servet
dc.contributor.authorSahinb, Gonul
dc.contributor.authorBaydar, Terken
dc.date.accessioned2019-12-16T10:09:32Z
dc.date.available2019-12-16T10:09:32Z
dc.date.issued2013
dc.identifier.issn0933-4807
dc.identifier.urihttps://doi.org/10.1515/pterid-2013-0008
dc.identifier.urihttp://hdl.handle.net/11655/19928
dc.description.abstractIncreased neopterin concentrations and altered tryptophan degradation are observed in diseases concomitant with cellular immune activation. This may be involved in the pathogenesis of several age-related disorders such as neurodegenerative disorders, autoimmune diseases, cardiovascular system disorders and malignancies. Therefore, in the present study, the evaluation of immune system activation by determination of tryptophan degradation and serum neopterin levels was carried out in volunteers aged >= 65 and <65 years old. The kynurenine-to-tryptophan ratio was calculated to estimate indoleamine-(2,3)-dioxygenase (IDO) activity. Tryptophan levels in the elderly (53.1 +/- 1.6 mu mol/L) were lower than individuals under 65 years (61.4 +/- 2.2 mu mol/L), whereas kynurenine concentrations in geriatrics and adults were 5.0 +/- 0.2 mu mol/L and 4.3 +/- 0.2 mu mol/L, respectively (both p<0.05). The kynurenine-to-tryptophan ratio was also significantly higher in geriatrics (92.1 +/- 3.2) than adults (73.5 +/- 2.8) (p<0.05). Neopterin levels were slightly higher in geriatrics compared to adults under 65 years old (p>0.05). Effects of gender, smoking habit, pathology and drug use on measured parameters were also evaluated. In conclusion, our findings show that aging is associated with immune activation, and immune activation may be induced by the number of existing pathologies as well as the number of drugs used.
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.isversionof10.1515/pterid-2013-0008
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiochemistry & Molecular Biology
dc.subjectBiophysics
dc.titleTryptophan Degradation And Neopterin Levels By Aging
dc.typeinfo:eu-repo/semantics/article
dc.relation.journalPteridines
dc.contributor.departmentFarmasötik Toksikoloji
dc.identifier.volume24
dc.identifier.issue1
dc.identifier.startpage33
dc.identifier.endpage39
dc.indexingWoS
dc.indexingScopus


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