• Türkçe
    • English
  • English 
    • Türkçe
    • English
  • Login
View Item 
  •   DSpace Home
  • Eczacılık Fakültesi
  • Eczacılık Meslek Bilimleri Bölümü
  • Eczacılık Meslek Bilimleri Bölümü Makale Koleksiyonu
  • View Item
  •   DSpace Home
  • Eczacılık Fakültesi
  • Eczacılık Meslek Bilimleri Bölümü
  • Eczacılık Meslek Bilimleri Bölümü Makale Koleksiyonu
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Design, Synthesis And In Vivo/In Vitro Screening Of Novel Chlorokojic Acid Derivatives

View/Open
licence.txt (265bytes)
Design synthesis and in vivo in vitro screening of novel chlorokojic acid derivatives.pdf (871.8Kb)
Date
2013
Author
Karakaya, Gülşah
Aytemir, Mutlu Dilsiz
Özçelik, Berrin
Calis, Ünsal
xmlui.mirage2.itemSummaryView.MetaData
Show full item record
Abstract
A series of novel Mannich bases of chlorokojic acid (2-chloromethyl-5-hydroxy-4H-pyran-4-one) were synthesized and their biological activities were investigated. Anticonvulsant activity results according to phase-I tests of Antiepileptic Drug Development (ADD) Program revealed that compound 13 was the most effective one at 4 h against subcutaneous pentylenetetrazole (scPTZ)-induced seizure test. Antimicrobial activities were evaluated in vitro against bacteria and fungi by using broth microdilution method. The antitubercular activities against Mycobacterium tuberculosis and M. avium were discussed with Resazurin microplate assay (REMA). The antimicrobial activity results indicated that compounds 1 and 12 (MIC: 8-16 mu g/mL) showed higher activity against Gram negative bacteria while compound 12 had MIC: 4-16 mu g/mL against Gram positive bacteria. Compound 1 was the most active one with MIC values of 8-32 mu g/mL against fungi. Mannich bases also exhibit significant antitubercular activity in a MIC range of 4 to 32 mu g/mL, especially compound 18 against M. avium.
URI
https://doi.org/10.3109/14756366.2012.666538
http://hdl.handle.net/11655/19964
xmlui.mirage2.itemSummaryView.Collections
  • Eczacılık Meslek Bilimleri Bölümü Makale Koleksiyonu [161]
Hacettepe Üniversitesi Kütüphaneleri
Açık Erişim Birimi
Beytepe Kütüphanesi | Tel: (90 - 312) 297 6585-117 || Sağlık Bilimleri Kütüphanesi | Tel: (90 - 312) 305 1067
Bizi Takip Edebilirsiniz: Facebook | Twitter | Youtube | Instagram
Web sayfası:www.library.hacettepe.edu.tr | E-posta:openaccess@hacettepe.edu.tr
Sayfanın çıktısını almak için lütfen tıklayınız.
Contact Us | Send Feedback



DSpace software copyright © 2002-2016  DuraSpace
Theme by 
Atmire NV
 

 


DSpace@Hacettepe
huk openaire onayı
by OpenAIRE

About HUAES
Open Access PolicyGuidesSubcriptionsContact

livechat

sherpa/romeo

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsTypeDepartmentPublisherLanguageRightsIndexing SourceFundingxmlui.ArtifactBrowser.Navigation.browse_subtypeThis CollectionBy Issue DateAuthorsTitlesSubjectsTypeDepartmentPublisherLanguageRightsIndexing SourceFundingxmlui.ArtifactBrowser.Navigation.browse_subtype

My Account

LoginRegister

Statistics

View Usage Statistics

DSpace software copyright © 2002-2016  DuraSpace
Theme by 
Atmire NV