Show simple item record

dc.contributor.authorKarakaya, Gulsah
dc.contributor.authorAytemir, Mutlu Dilsiz
dc.contributor.authorOzcelik, Berrin
dc.contributor.authorCalis, Unsal
dc.date.accessioned2019-12-16T10:09:46Z
dc.date.available2019-12-16T10:09:46Z
dc.date.issued2013
dc.identifier.issn1475-6366
dc.identifier.urihttps://doi.org/10.3109/14756366.2012.666538
dc.identifier.urihttp://hdl.handle.net/11655/19964
dc.description.abstractA series of novel Mannich bases of chlorokojic acid (2-chloromethyl-5-hydroxy-4H-pyran-4-one) were synthesized and their biological activities were investigated. Anticonvulsant activity results according to phase-I tests of Antiepileptic Drug Development (ADD) Program revealed that compound 13 was the most effective one at 4 h against subcutaneous pentylenetetrazole (scPTZ)-induced seizure test. Antimicrobial activities were evaluated in vitro against bacteria and fungi by using broth microdilution method. The antitubercular activities against Mycobacterium tuberculosis and M. avium were discussed with Resazurin microplate assay (REMA). The antimicrobial activity results indicated that compounds 1 and 12 (MIC: 8-16 mu g/mL) showed higher activity against Gram negative bacteria while compound 12 had MIC: 4-16 mu g/mL against Gram positive bacteria. Compound 1 was the most active one with MIC values of 8-32 mu g/mL against fungi. Mannich bases also exhibit significant antitubercular activity in a MIC range of 4 to 32 mu g/mL, especially compound 18 against M. avium.
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.isversionof10.3109/14756366.2012.666538
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiochemistry & Molecular Biology
dc.subjectPharmacology & Pharmacy
dc.titleDesign, Synthesis And In Vivo/In Vitro Screening Of Novel Chlorokojic Acid Derivatives
dc.typeinfo:eu-repo/semantics/article
dc.relation.journalJournal Of Enzyme Inhibition And Medicinal Chemistry
dc.contributor.departmentFarmasötik Kimya
dc.identifier.volume28
dc.identifier.issue3
dc.identifier.startpage627
dc.identifier.endpage638
dc.indexingWoS
dc.indexingScopus


Files in this item

This item appears in the following Collection(s)

Show simple item record