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dc.contributor.authorAnlar, Hatice Gul
dc.contributor.authorBacanli, Merve
dc.contributor.authorCal, Tugbagul
dc.contributor.authorAydin, Sevtap
dc.contributor.authorAri, Nuray
dc.contributor.authorUndeger Bucurgat, Ulku
dc.contributor.authorBasaran, Arif Ahmet
dc.contributor.authorBasaran, Ayse Nursen
dc.date.accessioned2019-12-16T10:09:47Z
dc.date.available2019-12-16T10:09:47Z
dc.date.issued2018
dc.identifier.issn1300-0144
dc.identifier.urihttps://doi.org/10.3906/sag-1708-8
dc.identifier.urihttp://hdl.handle.net/11655/19967
dc.description.abstractBackground/aim: Diabetes mellitus (DM) is a major health problem worldwide. Cinnamic acid (CA) and its derivatives are synthesized in plants and increasing attention has been given to them in recent years due to the high number of beneficial health properties attributed to their consumption. The aim of this study was to investigate the effects of CA on streptozotocin-induced diabetes in Wistar albino rats. Materials and methods: DNA damage was evaluated in the blood, liver, and kidney cells of rats by the alkaline comet assay. Oxidative stress parameters such as catalase, superoxide dismutase, glutathione reductase, glutathione-S-transferase, and glutathione peroxidase activities and 8-hydroxy-2'-deoxyguanosine, total glutathione, and malondialdehyde levels; biochemical parameters including insulin, total bilirubin, and BCA protein levels; hepatic enzyme levels such as alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and gamma-glutamyl transferase; and lipid profile parameters including high-density lipoprotein, low-density lipoprotein, total cholesterol, and triglyceride levels were also evaluated. Results: DM caused genotoxic damage and alterations in lipid profiles, oxidative stress parameters, and hepatic enzymes levels. CA treatment ameliorated these effects. Conclusion: It seems that CA might have a role in the prevention of the complications of diabetes.
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkey
dc.relation.isversionof10.3906/sag-1708-8
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGeneral & Internal Medicine
dc.titleEffects Of Cinnamic Acid On Complications Of Diabetes
dc.typeinfo:eu-repo/semantics/article
dc.relation.journalTurkish Journal Of Medical Sciences
dc.contributor.departmentFarmasötik Toksikoloji
dc.identifier.volume48
dc.identifier.issue1
dc.identifier.startpage168
dc.identifier.endpage177
dc.indexingWoS
dc.indexingScopus


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