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dc.contributor.authorPalabiyik, Saziye Sezin
dc.contributor.authorAsci, Ali
dc.contributor.authorGirgin, Gozde
dc.contributor.authorSahin, Gonul
dc.contributor.authorCetinkaya, Ramazan
dc.contributor.authorBaydar, Terken
dc.date.accessioned2019-12-16T10:09:49Z
dc.date.available2019-12-16T10:09:49Z
dc.date.issued2013
dc.identifier.issn0933-4807
dc.identifier.urihttps://doi.org/10.1515/pterid-2013-0030
dc.identifier.urihttp://hdl.handle.net/11655/19978
dc.description.abstractEnd-stage renal disease (ESRD) is the inability of the kidneys to remove waste products from the blood. The most important factors causing ESRD that require hemodialysis are diabetes and hypertension. There are limited numbers of studies to evaluate tetrahydrobiopterin pathway in these patients. The aim of the study was to evaluate tetrahydrobiopterin pathway by measuring its important components, biopterin to creatinine concentrations and dihydropteridine reductase activities in diabetes and hypertension patients treated with/without hemodialysis. The patients undergoing hemodialysis were classified as diabetic nephropathy (n=21), hypertensive nephropathy (n=20) and others (n=30), while the controls consisted of healthy subjects (n=21), diabetic subjects (n=23) and hypertensive subjects (n=22) without any renal disorder. It was found that urinary biopterin to creatinine concentrations significantly increased in kidney failure patients undergoing hemodialysis compared to the healthy control group (p<0.05). Additionally, there were significant differences in urinary biopterin to creatinine concentrations between diabetes or hypertension patients and their hypertensive or diabetic control counterparts (both p<0.05). Our results indicated an alteration in tetrahydrobiopterin pathway in ESRD, and in the presence of secondary pathologies such as diabetes and hypertension in the patients undergoing hemodialysis, more considerable changes are observed in the pathway.
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.isversionof10.1515/pterid-2013-0030
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiochemistry & Molecular Biology
dc.subjectBiophysics
dc.titleEvaluation Of Dihydropteridine Reductase Activities In Patients With Kidney Failure
dc.typeinfo:eu-repo/semantics/article
dc.relation.journalPteridines
dc.contributor.departmentFarmasötik Toksikoloji
dc.identifier.volume24
dc.identifier.issue4-Mar
dc.identifier.startpage219
dc.identifier.endpage223
dc.indexingWoS
dc.indexingScopus


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