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dc.contributor.authorRenda, Gulin
dc.contributor.authorOzgen, Ufuk
dc.contributor.authorUnal, Zeynep
dc.contributor.authorSabuncuoglu, Suna
dc.contributor.authorPalaska, Erhan
dc.contributor.authorOrhan, Ilkay Erdogan
dc.date.accessioned2019-12-16T10:09:50Z
dc.date.available2019-12-16T10:09:50Z
dc.date.issued2017
dc.identifier.issn1307-6167
dc.identifier.urihttps://doi.org/10.25135/acg.rnp.61.17.03.057
dc.identifier.urihttp://hdl.handle.net/11655/19982
dc.description.abstractTrifolium L. species with a rich isoflavone content have been used as expectorant, analgesic, antiseptic, tonic, and wound- healer in folk medicine. The aim of the study is to evaluate pharmacological properties of the extracts and isolated compounds of T. tricocephalum. Phytochemical investigation of the aerial parts of T. trichocephalum led to the isolation of daidzein, genistein, quercetin, and daidzein 4'-O-beta-glucoside for the first time from this species. Isolated compounds along with the methanol extract, water, ethyl acetate and chloroform subextracts were tested for their radical scavenging and cytotoxic activity which was evaluated by MTT assay. According to the results of activity tests, extracts showed a concentration-dependent radical scavenging activity as well as cytotoxic effect on HepG2 cells at 400 mu g/mL, whereas the compounds did not exert any obvious cytotoxic effect at tested concentrations.
dc.language.isoen
dc.publisherAcg Publications
dc.relation.isversionof10.25135/acg.rnp.61.17.03.057
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPlant Sciences
dc.subjectChemistry
dc.subjectPharmacology & Pharmacy
dc.titleFlavonoid Derivatives From The Aerial Parts Of Trifolium Trichocephalum M. Bieb. And Their Antioxidant And Cytotoxic Activity
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalRecords Of Natural Products
dc.contributor.departmentFarmasötik Toksikoloji
dc.identifier.volume11
dc.identifier.issue5
dc.identifier.startpage479
dc.identifier.endpage484
dc.indexingWoS


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