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dc.contributor.authorYilmaz, Bilal
dc.contributor.authorAsci, Ali
dc.contributor.authorErdem, Ali Fuat
dc.date.accessioned2019-12-16T10:09:53Z
dc.date.available2019-12-16T10:09:53Z
dc.date.issued2014
dc.identifier.issn0021-9665
dc.identifier.urihttps://doi.org/10.1093/chromsci/bmt080
dc.identifier.urihttp://hdl.handle.net/11655/19991
dc.description.abstractA simple high-performance liquid chromatography method has been developed for the determination of naproxen in human plasma. The method was validated on an Ace C18 column using ultraviolet detection. The mobile phase consisted of 20 mM phosphate buffer (pH 7) containing 0.1% trifluoroacetic acid-acetonitrile (65:35, v/v). The calibration curve was linear between the concentration ranges of 0.10 and 5.0 mu g/mL. Intra-day and inter-day precision values for naproxen in plasma were less than 4.84, and accuracy (relative error) was better than 3.67%. The extraction recovery values of naproxen from human plasma were between 91.0 and 98.9%. The limits of detection and quantification of naproxen were 0.03 and 0.10 mu g/mL, respectively. Also, this assay was applied to determine the pharmacokinetic parameters of naproxen in six healthy Turkish volunteers who had been given 220 mg of naproxen.
dc.language.isoen
dc.publisherOxford Univ Press Inc
dc.relation.isversionof10.1093/chromsci/bmt080
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiochemistry & Molecular Biology
dc.subjectChemistry
dc.titleHplc Method For Naproxen Determination In Human Plasma And Its Application To A Pharmacokinetic Study In Turkey
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalJournal Of Chromatographic Science
dc.contributor.departmentFarmasötik Toksikoloji
dc.identifier.volume52
dc.identifier.issue7
dc.identifier.startpage584
dc.identifier.endpage589
dc.indexingWoS
dc.indexingScopus


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