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dc.contributor.authorFaraj, Jabar A.
dc.contributor.authorDorati, Rossella
dc.contributor.authorSchoubben, Aurelie
dc.contributor.authorWorthen, David
dc.contributor.authorSelmin, Francesca
dc.contributor.authorCapan, Yilmaz
dc.contributor.authorLeung, Kai
dc.contributor.authorDeLuca, Patrick P.
dc.date.accessioned2019-12-16T10:18:11Z
dc.date.available2019-12-16T10:18:11Z
dc.date.issued2007
dc.identifier.issn1530-9932
dc.identifier.urihttps://doi.org/10.1208/pt0801026
dc.identifier.urihttp://hdl.handle.net/11655/20026
dc.description.abstractThe objective of this study was to characterize the stability of KSL-W, an antimicrobial decapeptide shown to inhibit the growth of oral bacterial strains associated with caries development and plaque formation, and its potential as an antiplaque agent in a chewing gum formulation. KSL-W formulations with or without the commercial antibacterial agent cetylpyridinium chloride (CPC) were prepared. The release of KSL-W from the gums was assessed in vitro using a chewing gum apparatus and in vivo by a chew-out method. A reverse-phase high-performance liquid chromatography method was developed for assaying KSL-W. Raw material stability and temperature and pH effects on the stability of KSL-W solutions and interactions of KSL-W with tooth-like material, hydroxyapatite discs, were investigated. KSL-W was most stable in acidic aqueous solutions and underwent rapid hydrolysis in base. It was stable to enzymatic degradation in human saliva for 1 hour but was degraded by pancreatic serine proteases. KSL-W readily adsorbed to hydroxyapatite, suggesting that it will also adsorb to the teeth when delivered to the oral cavity. The inclusion of CPC caused a large increase in the rate and extent of KSL-W released from the gums. The gum formulations displayed promising in vitro/ in vivo release profiles, wherein as much as 90% of the KSL-W was released in a sustained manner within 30 minutes in vivo. These results suggest that KSL-W possesses the stability, adsorption, and release characteristics necessary for local delivery to the oral cavity in a chewing gum formulation, thereby serving as a novel antiplaque agent.
dc.language.isoen
dc.publisherSpringer
dc.relation.isversionof10.1208/pt0801026
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPharmacology & Pharmacy
dc.titleDevelopment Of A Peptide-Containing Chewing Gum As A Sustained Release Antiplaque Antimicrobial Delivery System
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalAaps Pharmscitech
dc.contributor.departmentFarmasötik Teknoloji
dc.identifier.volume8
dc.identifier.issue1
dc.indexingWoS


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