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dc.contributor.authorErdogan, Bulent
dc.contributor.authorBavbek, Murad
dc.contributor.authorSahin, Iffet Feride
dc.contributor.authorCaner, Hakan
dc.contributor.authorOzen, Ozlem
dc.contributor.authorDenkbas, Emir Baki
dc.contributor.authorAltinors, Mehmet Nur
dc.date.accessioned2019-12-16T10:29:21Z
dc.date.available2019-12-16T10:29:21Z
dc.date.issued2010
dc.identifier.issn1019-5149
dc.identifier.urihttps://doi.org/
dc.identifier.urihttp://hdl.handle.net/11655/20099
dc.description.abstractAIM: The objective of this study was to investigate whether the transplantation of fetal umbilical cord tissue cells as a source of stem cells into the acutely injured spinal cord would produce some regenerations and/or functional recovery in a rat model of spinal cord injury. MATERIAL and METHODS: Material and Methods: Five pregnant albino Wistar rats of 12 days gestation were used for obtaining art umbilical cord cell graft. At the second stage of the experiment only Th8-Th9 laminectomy was performed in Group A animals while Group B animals underwent spinal cord hemitransection. The cultured fetal umbilical cord cells coated with Alginate Gel were placed into the lesion cavity immediately after surgery in Group C animals. Group D animals received only Alginate gel sponges into the injured area. All experiment groups were analyzed histologically and immunohistochemically (GFAP, Ki-67, and Pan cadherin) and for motor function after surgery. RESULTS: Results: The umbilical cord cell transplanted animals showed a significant motor recovery compared to non-transplanted animals at 8 and 21 days after spinal cord injury (p=0.008). Significant GFAP and Ki-67 expressions were noted in transplanted animals (p=0.048) suggesting astroglial proliferation. CONCLUSION: Our findings support the possibility of some functional recovery after umbilical cord cell transplantation following spinal cord injury.
dc.language.isoen
dc.publisherTurkish Neurosurgical Soc
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNeurosciences & Neurology
dc.subjectSurgery
dc.titleFetal Allogeneic Umbilical Cord Cell Transplantation Improves Motor Function In Spinal Cord-Injured Rats
dc.title.alternativeAllojenik Fetal Göbek Kordonu Hücrelerinin Transplantasyonu Omurilik Hasarl› S›çanlarda Motor Fonksiyonu ‹yilefltirir
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalTurkish Neurosurgery
dc.contributor.departmentBiyokimya
dc.identifier.volume20
dc.identifier.issue3
dc.identifier.startpage286
dc.identifier.endpage294
dc.indexingWoS
dc.indexingScopus


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