Di (2-Etilhekzil) Fitalatın Pubertal Dönemdeki Erkek Sıçanlarda Genotoksik, Histolojik ve Biyokimyasal Etkilerinin Araştırılması
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In the present study, we investigated the genotoxic effects of DEHP which is widely used as a plasticizer and people were exposed in daily life on pubertal male rats. These effects were investigated with Comet assay and histopathological, hematological and biochemical analysis were investigated. For this purpose, rats were divided into 5 groups and each group had 6 animals. The dose groups were oil control, positive control (MMS), 100 mg kg day, 200 mg kg day and 400 mg kg day of DEHP. It was administered daily to the rats by oral gavage for 28 days and every week until the end of the experiment, genotoxic effect was measured in blood. During the experiment, body weights and feed and water consumption were recorded.