Mirisetinin Peripubertal Dönemdeki Erkek Sıçanlarda Tiroid Gonadal Eksen Üzerine Etkilerinin Araştırılması
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In the present study, we investigated the estrogenic effects of myricetin comparing with 17β estradiol via ʺPubertal development and thyroid function in intact peripubertal male ratsʺ assay. For this purpose, myricetin was administered at 25 mg kg day and 50 mg kg day dose levels by gavage for 30 days. During the experiment, the day of preputial seperation (PPS) and the body weights on the day of PPS were determined in rats. At the end of the experiment period blood samples were taken and whole blood count performed while T3,TSH and T4 hormone levels and alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), total protein, albumine, creatinine, lactate dehydrogenase (LDH) and glucose levels were determined in serum samples. Testis, epididymes, seminal vesicle, prostate and thyroid were dissected and potential histopathologic findings monitorized in different magnifications by light microscopy.