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dc.contributor.authorAlkan, S.S.
dc.contributor.authorBush, M.E.
dc.contributor.authorNitecki, D.E.
dc.contributor.authorGoodman, J.W.
dc.date.accessioned2020-01-21T07:39:23Z
dc.date.available2020-01-21T07:39:23Z
dc.date.issued1972
dc.identifier.issn0022-1007
dc.identifier.urihttps://doi.org/10.1084/jem.136.2.387
dc.identifier.urihttps://www.scopus.com/inward/record.url?eid=2-s2.0-0015382868&partnerID=40&md5=eee8c96bc7e23cf90d88c9df4bf4a147
dc.identifier.urihttp://hdl.handle.net/11655/21854
dc.description.abstractThe low molecular weight compound L-tyrosine-azobenzenearsonate (RAT) induces a cellular immune response in guinea pigs. The contribution of the side chain of tyrosine to the immunogenicity of RAT and the structural requirements at that position for immunogenicity were assessed by synthesizing a series of analogs of RAT containing modifications in the side chain of tyrosine and employing them as immunogens. Removal of either the carboxyl or amino group did not markedly affect immunogenicity, measured by the induction of delayed cutaneous sensitivity, whereas deletion of both completely abolished it. However, a charged group was not required since side chains containing a polar hydroxyl group could substitute for chains bearing an amino or carboxyl group. The size of the side chain exerted a pronounced influence; the charged or polar substituent had to be extended from the phenolic ring by at least two carbon atoms in order to confer immunogenicity.tr_TR
dc.language.isoengtr_TR
dc.publisherThe Rockefeller University Presstr_TR
dc.relation.isversionof10.1084/jem.136.2.387tr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.subjectAntibody formationtr_TR
dc.subjectGuinea pigstr_TR
dc.subjectOrganoarsenic derivativetr_TR
dc.subjectStructure-activity relationshiptr_TR
dc.subject.lcshKonu Başlıkları Listesi::Tıptr_TR
dc.titleAntigen Recognition And The Immune Response: Structural Requirements In The Side Chain Of Tyrosine For Immunogenicity Of L-Tyrosine-Azobenzenearsonatetr_TR
dc.typeinfo:eu-repo/semantics/articletr_TR
dc.relation.journalJournal of Experimental Medicinetr_TR
dc.contributor.departmentMikrobiyolojitr_TR
dc.identifier.volume136tr_TR
dc.identifier.issue2tr_TR
dc.identifier.startpage387tr_TR
dc.identifier.endpage391tr_TR
dc.indexingScopustr_TR
dc.fundingYoktr_TR


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