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dc.contributor.authorRubini, Mauro
dc.contributor.authorErdal, Yılmaz Selim
dc.contributor.authorSpigelman, Mark
dc.contributor.authorZaio, Paola
dc.contributor.authorDonoghue, Helen
dc.date.accessioned2020-01-30T10:51:42Z
dc.date.available2020-01-30T10:51:42Z
dc.date.issued2014
dc.identifier.issn1047-482X
dc.identifier.urihttps://doi.org/10.1002/oa.2242
dc.identifier.urihttp://hdl.handle.net/11655/21958
dc.description.abstractThis study is based on the paleaopathology of leprosy on human skeletal remains and the detection of ancient Mycobacterium leprae DNA. Two cases of childhood leprosy were recognized. The first case was in a Roman necropolis at Martellona (Rome, Central Italy), dated to the 2nd to 3rd centuries ce. The skeleton of a child aged 4-5years, from tomb 162, is the youngest individual in Italy from this time period, with the clear rhino-maxillary syndrome and other bony changes indicative of leprosy. The second case from a burial at Kovuklukaya, in the Sinop region of Northern Turkey, was from the 8th to the 10th centuries, during the Byzantine era. The endocranium of a 4-5-month-old infant with new bone formationan indication of chronic inflammationwas positive for M. leprae DNA. Infant and childhood leprosy is uncommon today, and there is a scarcity of information in the osteoarchaeological literature of leprosy in the past, especially in children. The significance of these cases is that it adds to an understanding of the history of the disease in the former Roman Empire. It is hoped that over time sufficient data can be obtained to understand the epidemiological dynamics and clinical evolution of leprosy from the ancient period until today. Copyright (c) 2012 John Wiley & Sons, Ltd.tr_TR
dc.language.isoentr_TR
dc.publisherWileytr_TR
dc.relation.isversionof10.1002/oa.2242tr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.subject2nd to 3rd centuries CEtr_TR
dc.subject8th to 10th centuries CEtr_TR
dc.subjectByzantine periodtr_TR
dc.subjectCentral Italytr_TR
dc.subjectTurkeytr_TR
dc.subjectLeprosytr_TR
dc.subject.lcshAntropolojitr_TR
dc.titlePaleopathological and Molecular Study on Two Cases of Ancient Childhood Leprosy From the Roman and Byzantine Empirestr_TR
dc.typeinfo:eu-repo/semantics/articletr_TR
dc.relation.journalInternational Journal Of Osteoarchaeologytr_TR
dc.contributor.departmentAntropolojitr_TR
dc.identifier.volume24tr_TR
dc.identifier.issue5tr_TR
dc.identifier.startpage570tr_TR
dc.identifier.endpage582tr_TR
dc.indexingWoStr_TR
dc.fundingYoktr_TR


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