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dc.contributor.authorMendi, Ayşegül
dc.contributor.authorGökçınar Yağcı, Beyza
dc.contributor.authorKızıloğlu, Mustafa
dc.contributor.authorSaraç, Nurdan
dc.contributor.authorUğur, Aysel
dc.contributor.authorYılmaz, Derviş
dc.contributor.authorUçkan, Duygu
dc.date.accessioned2020-02-17T11:34:37Z
dc.date.available2020-02-17T11:34:37Z
dc.date.issued2017
dc.identifier.issn1516-8913
dc.identifier.urihttps://doi.org/10.1590/1678-4324-2017160391
dc.identifier.urihttp://hdl.handle.net/11655/22150
dc.description.abstractA natural agent that maintains mesenchymal stem cell (MSCs) viability, promotes osteogenic differentiation while modulating the immunological response could achieve success in regeneration during healing and may also prevent bone resorption and improve regeneration. We aimed to demonstrate that a Thymbra spicata var. intricata extract could induce proliferation, differentiation, and modulate the immune responses of mesenchymal stem cells (MSCs). Using xCELLigence, a real-time monitoring system, we obtained a growth curve of MSCs. A dose of 10 mu g/mL was the most efficient concentration for vitality. Osteogenic differentiation and antiinflammatory activities were determined by using an ELISA Kit to detect early and late markers of differentiation. The Osteonectin (ON, early osteogenic marker) level decreased while the Osteocalcin (OCN, late osteogenic marker) level increased in the T. spicata var. intricata treated group, suggesting that T. spicata var. intricata may accelerate osteogenic differentiation. Reduced level of the IL-6 cytokine in repsonse to TNF-alpha was evident. T. spicata var. intricata could be a promising osteogenic inducer in dentistry and could be used safely in biocomposites or scaffold fabrications.tr_TR
dc.language.isoengtr_TR
dc.publisherInst Tecnologia Paranatr_TR
dc.relation.isversionof10.1590/1678-4324-2017160391tr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.subjectMesenchymal stem celltr_TR
dc.subjectOsteogenic differentiationtr_TR
dc.subjectT. spicata var. intricatatr_TR
dc.subjectBone regenerationtr_TR
dc.subject.lcshKök Hücretr_TR
dc.titleThymbra Spicata Var. Intricata Induces Mesenchymal Stem Cell Proliferation And Osteogenic Differentiationtr_TR
dc.typeinfo:eu-repo/semantics/articletr_TR
dc.relation.journalBrazilian Archives Of Biology And Technologytr_TR
dc.contributor.departmentKök Hücretr_TR
dc.identifier.volume60tr_TR
dc.indexingWoStr_TR
dc.indexingScopustr_TR
dc.fundingYoktr_TR


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