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dc.contributor.authorVural, Birol
dc.contributor.authorCantürk, Nuh Zafer
dc.contributor.authorEsen, Nilüfer
dc.contributor.authorSolakoğlu, Seyhun
dc.contributor.authorCantürk, Zeynep
dc.contributor.authorKırkalı, Gürdal
dc.contributor.authorSökmensüer, Cenk
dc.date.accessioned2020-03-10T10:39:23Z
dc.date.available2020-03-10T10:39:23Z
dc.date.issued1999
dc.identifier.issn0268-1161
dc.identifier.urihttps://doi.org/10.1093/humrep/14.1.49
dc.identifier.urihttp://hdl.handle.net/11655/22270
dc.description.abstractThe most common cause of intraperitoneal adhesions which may result in infertility and intestinal obstruction is previous abdominal surgery. Surgical trauma of the peritoneum in the absence of infection elicits a rapid and transient influx of polymorphonuclear leukocytes (PMN) into the peritoneal cavity, The role of neutrophils in intraperitoneal adhesion formation has not been studied. We aimed to study the effects of PMN counts and PMN functions on peritoneal adhesion formation. Forty peritoneal adhesion-induced rats were randomly divided into three groups; group I, receiving saline; group LI, receiving cyclophosphamide; and group III, receiving granulocyte-macrophage colony-stimulating factor (GM-CSF), In all groups, peritoneal lavage was performed to determine PMN counts the day after adhesion induction. Blood neutrophil counts and neutrophil functions were also determined. Adhesions were evaluated blindly 14 days after the operation. Adhesion tissue samples were microscopically evaluated. Tissue hydroxyproline and collagen concentrations were measured. The neutrophil counts and phagocytosis significantly increased in group III and neutrophil counts decreased in group II (P < 0.05), The score of adhesion formation in group II was significantly less than that in groups I and III (P < 0.05). Hydroxyproline concentrations of adhesion tissue were significantly decreased in group II when compared with group III (P < 0.05). The present study shows that neutropenia lowers the degree of postoperative adhesion formation. It is concluded that PMN may have a role to play in modulating post-operative adhesion formation.tr_TR
dc.language.isoentr_TR
dc.publisherOxford Univ Presstr_TR
dc.relation.isversionof10.1093/humrep/14.1.49tr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.subjectCyclophosphamidetr_TR
dc.subjectGranulocyte–macrophage colonystimulating factortr_TR
dc.subjectNeutrophilstr_TR
dc.subjectPeritoneumtr_TR
dc.subjectPostoperative complicationstr_TR
dc.subject.lcshR/W - Tıptr_TR
dc.titleThe Role Of Neutrophils In The Formation Of Peritoneal Adhesionstr_TR
dc.typeinfo:eu-repo/semantics/articletr_TR
dc.typeinfo:eu-repo/semantics/publishedVersiontr_TR
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalHuman Reproductiontr_TR
dc.contributor.departmentTıbbi Patolojitr_TR
dc.identifier.volume14tr_TR
dc.identifier.issue1tr_TR
dc.identifier.startpage49tr_TR
dc.identifier.endpage54tr_TR
dc.indexingWoStr_TR
dc.indexingScopustr_TR
dc.fundingYoktr_TR


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