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dc.contributor.authorBahadir, S
dc.contributor.authorNarin, F
dc.contributor.authorBasar, I
dc.contributor.authorHanalioglu, S
dc.contributor.authorBilginer, B
dc.contributor.authorAkalan, N
dc.date.accessioned2020-11-23T10:28:19Z
dc.date.available2020-11-23T10:28:19Z
dc.date.issued2020
dc.identifier.urihttps://doi.org/10.1080/00207454.2020.1760268
dc.identifier.urihttp://hdl.handle.net/11655/23145
dc.description.abstractObjects: Cerebral vasospasm is an important event that occurs following subarachnoid hemorage which has significant mortality and morbidity. The goal in this study was to investigate the effect of pentoxifylline on vasospasm in an experimental subarachnoid hemorrhage model.Methods: In this study, 20 male New Zeland White rabbits weighing 3000-3500 g were assigned randomly to four groups. Animals in group 1 served as controls. Animals in group two received only intravenous pentoxifylline injection 3 times in 12 h intervals. In group 3, SAH was induced and no injection was given. Animals in group 4 received intravenous pentoxifylline (6 mg/kg) injections 3 times at 12th, 24th and 36th hours after subarachnoid hemorrhage induction. All animals were sacrificed and basilar arteries were removed at 48th hour. Basilar artery vessel diameters, wall thicknesses and luminal section areas were measured with Spot for Windows version 4.1. Statistical analysis was performed using ANOVA and Kruskall-Wallis tests.Results: Mean basilar artery luminal section areas and luminal diameters in group 4 were significantly higher compared to group 3 (p < 0.05). Basilar artery wall thicknesses and were found to be higher in group 3 than in other groups and this was also statistically significant (p < 0.05).Conclusion: Our study demonstrated that intravenous administration of pentoxifylline significantly decreases vasospasm after subarachnoid hemorrhage.tr_TR
dc.language.isoengtr_TR
dc.publisherTaylor and Francistr_TR
dc.relation.isversionof10.1080/00207454.2020.1760268tr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.rightsAttribution 4.0 United States
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectpentoxifyllinetr_TR
dc.subjectsubarachnoid hemorrhagetr_TR
dc.subjectcerebral vasospasmtr_TR
dc.subjectbasilar arterytr_TR
dc.subject.lcshCerrahitr_TR
dc.titleThe effect of pentoxifylline on cerebral vasospasm following experimental subarachnoid hemorrhagetr_TR
dc.typeinfo:eu-repo/semantics/articletr_TR
dc.typeinfo:eu-repo/semantics/publishedVersiontr_TR
dc.relation.journalInternational Journal of Neurosciencetr_TR
dc.contributor.departmentBeyin ve Sinir Cerrahisitr_TR
dc.identifier.volumeMaytr_TR
dc.identifier.issue3tr_TR
dc.identifier.startpage1tr_TR
dc.identifier.endpage5tr_TR
dc.indexingWoStr_TR
dc.fundingYoktr_TR


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