Browsing Eczacılık Meslek Bilimleri Bölümü Makale Koleksiyonu by Department "Farmasötik Kimya"
Now showing items 1-18 of 18
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2,2,7,7-TetraMethyl-1,2,3,4,5,6,7,8-OctaHydroAcridine-1,8-Dione
(2012)The whole molecule of the title compound, C17H21NO2, is generated by twofold rotational symmetry. The N atom and the C and H atoms in position 4 of the pyridine ring lie on the twofold axis. The cyclohexene ring has a sofa ... -
3,3,6,6-TetraMethyl-9-(1-Methyl-1H-Indol-2-Yl)-1,2,3,4,5,6,7,8,9,10-DecaHydroAcridine-1,8-Dione
(2012)In the acridine system of the title molecule, C26H30N2O2, both cyclohex-2-enone rings adopt sofa conformations. The indole ring system is essentially planar, with a maximum deviation of 0.017 (2) Å for a bridgehead C ... -
(5-Chloro-1,3-Benzoxazol-2-Ylthio)Acetonitrile
(Munksgaard Int Publ Ltd, 1994)(5-Chloro-1,3-benzoxazol-2-ylthio)acetonitrile, C9H5-ClN2OS, was obtained by the reaction of chloro-acetonitrile with 5-chloro-2-mercaptobenzoxazole. The structure of the title compound was indicated by IR, H-1 NMR and ... -
9-(5-Bromo-1H-Indol-3-yl)-1,2,3,4,5,6,7,8,9,10-Decahydroacridine-1,8-Dione Dimethyl Sulfoxide Monosolvate
(2012)In the title compound, C21H19BrN2O2·C2H6OS, the indole ring system is essentially planar, with a maximum deviation of 0.050 (3) Å for the non-bridgehead C atom adjacent to the N atom. The two cyclohex-2-enone rings adopt ... -
Design, Synthesis And In Vivo/In Vitro Screening Of Novel Chlorokojic Acid Derivatives
(Taylor & Francis Ltd, 2013)A series of novel Mannich bases of chlorokojic acid (2-chloromethyl-5-hydroxy-4H-pyran-4-one) were synthesized and their biological activities were investigated. Anticonvulsant activity results according to phase-I tests ... -
Ethyl 2,7,7-Trimethyl-4-(1-Methyl-1H-Indol-3-Yl)-5-Oxo-1,4,5,6,7,8-HexaHydroQuinoline-3-CarboxylAte
(2012)In the title molecule, C24H28N2O3, the cyclohexene ring is in a sofa conformation and the 1,4-dihydropyridine ring is in a slight boat conformation. In the indole ring system, the pyrrole and benzene rings form a dihedral ... -
Ethyl 4-(5-Bromo-1H-Indol-3-Yl)-2,6,6-Trimethyl-5-Oxo-1,4,5,6,7,8-HexaHydroQuinoline-3-CarboxylAte
(2012)The title compound, C23H25BrN2O3, crystallizes with two independent molecules in the asymmetric unit (Z′ = 2) which differ in the twist of the 5-bromo-1H-indole ring with respect to the plane of the 4-methyl-1,4,5,6,7,8 ... -
Gpcr Modulation Of Thieno[2,3-B]Pyridine Anti-Proliferative Agents
(2017)A panel of docking scaffolds was developed for the known molecular targets of the anticancer agents, thieno[2,3-b]pyridines, in order to glean insight into their mechanism of action. The reported targets are the ... -
Microwave-Assisted Synthesis Of Condensed 1,4-Dihydropyridines As Potential Calcium Channel Modulators
(Scientific Technical Research Council Turkey-Tubitak, 2015)This study reports the design, synthesis, and calcium channel modulatory activity evaluation of a series of 14 novel fused 1,4-dihydropyridine derivatives. The molecular design of the compounds was based on modifications ... -
Novel Thiazolidinone-Azole Hybrids: Design, Synthesis And Antimycobacterial Activity Studies
(2016)To develop novel antimycobacterial agents, a new series of thiazolidinone-azole hybrids 4a-b, 5a-b and 6-13 were designed and synthesized. Thiazolidin-4-ones (4a-b and 5a-b) were obtained by the reaction of Schiff bases ... -
Novel Triazolothiadiazines Act As Potent Anticancer Agents In Liver Cancer Cells Through Akt And Ask-1 Proteins
(Pergamon-Elsevier Science Ltd, 2016)Newly designed triazolothiadiazines incorporating with structural motifs of nonsteroidal analgesic anti-inflammatory drugs were synthesized and screened for their bioactivity against epithelial cancer cells. Compounds with ... -
Structure-Activity Relationships Of Receptor Binding Of 1,4-Dihydropyridine Derivatives
(Pharmaceutical Soc Japan, 2008)The present study was undertaken to investigate binding activity of synthesized 1,4-dihydropyridine (1,4-DHP) derivatives (Compounds 1-124) to 1,4-DHP calcium channel antagonist receptors in rat brain. Sixteen 1,4-DHP ... -
Synthesis and Antioxidant Properties of Novel Benzimidazole Derivatives
(Taylor & Francis Ltd, 2004)Some novel benzimidazole derivatives carrying thiosemicarbazide and triazole moieties at the N1 position were synthesized and their in vitro effects on rat liver microsomal NADPH-dependent lipid peroxidation (LP) levels ... -
Synthesis And Biological Evaluation Of New Tricyclic Dihydropyridine Based Derivatives On Potassium Channels
(2016)The present study reports a microwave-assisted method for the synthesis of twelve novel tricyclic 1,4-dihydropyridine derivatives in which dimethyl-substituted cyclohexane and / or tetrahydrothiophene rings are fused to ... -
Synthesis, Structural Characterization and Myorelaxant Activity of 4-Naphthylhexahydroquinoline Derivatives Containing Different Ester Groups
(Serbian Chemical Soc, 2016)The present study reports the synthesis, structural characterization and myorelaxant activity evaluation of a series of 16 novel 4-naphthylhexahydroquinoline derivatives. The compounds were achieved by one-pot microwave-assisted ... -
Two 1,4-Dihydropyridine Derivatives With Potential Calcium-Channel Antagonist Activity
(Int Union Crystallography, 2011)The title compounds, benzyl 4-(3-chloro-2-fluorophenyl)-2-methyl-5-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[b]pyridine-3-carboxylate, C23H19ClFNO3, (I), and 3-pyridylmethyl 4-[2-fluoro-3-(trifluoromethyl)phenyl]-2,6,6-trimet ...
