Perfluorooctanoic acid (PFOA) is a persistent environmental pollutant of toxicological importance. However, its mechanism of toxicity was not well-characterized. The aim of this study was to investigate the possible ...

Temporal lobe epilepsy (TLE) model was generated at male Wistar rats by intraperitoneal (i.p.) injection of excitotoxic agent kainic acid (KA). This thesis work has been done as to investigate possible side-effects on ...

Hashimoto's thyroiditis (HT) is an autoimmune disease of thyroid gland. In the course of the disease, thyroid gland is attacked by a variety of cell- and antibody-mediated immune processes. It is reported that high iodine ...

In this study, forty two compounds which have 1-[2-(5-substituted-2- benzoxazolinone-3-yl)acetyl]-3,5-disubstitutedphenyl-4,5-dihydro-1H-pyrazole structure and nine compounds which have N’-(1,3-disubstitutedphenylallyl ...

The genus Astaragalus is represented by 445 species 224 of which are endemic in Turkish flora. Astragalus species have been used to obtain “gum tragacanth” for many years. Also, numerous Astragalus species have been used ...

It has been shown that genetic damage has an improtant role in the mechanisms of cancer and other chronic diseases that have been observed all over the world. Recently, theory about that epigenetic changes are also responsible ...

In this study sixteen 2,6,6-trimethyl-4-aryl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (compound 1-16) have been synthesized. The synthesis of the compounds was realised by the reaction of the 4,4-dimethyl-1,3-c ...