Browsing Temel Eczacılık Bilimleri Bölümü Makale Koleksiyonu by Publisher "Amer Assoc Cancer Research"

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In Vivo Inhibition Of Lung Cancer By Grn163L: A Novel Human Telomerase Inhibitor

Dikmen, ZG; Gellert, GC; Jackson, S; Gryaznov, S; Tressler, R; Dogan, P; Wright, WE; Shay, JW (Amer Assoc Cancer Research, 2005)

Differential regulation of telomerase activity in normal and tumor cells provides a rationale for the design of new classes of telomerase inhibitors. The telomerase enzyme complex presents multiple potential sites for the ...
Induction Of Telomere Dysfunction Mediated By The Telomerase Substrate Precursor 6-Thio-2'-Deoxyguanosine

Mender, Ilgen; Gryaznov, Sergei; Dikmen, Z. Gunnur; Wright, Woodring E.; Shay, Jerry W. (Amer Assoc Cancer Research, 2015)

The relationships between telomerase and telomeres represent attractive targets for new anticancer agents. Here, we report that the nucleoside analogue 6-thio-2'-deoxyguanosine (6-thio-dG) is recognized by telomerase and ...