Yüzey Zenginleştirilmiş Raman Spektroskopisi (Sers) için Nano-Yaklaşım Temelli Platformların Geliştirilmesi ve Tanı Amaçlı Uygulanması
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Surface-Enhanced Raman Spectroscopy (SERS) has attracted increasing interest as a powerful analytical tool for the detection of chemical and biological molecules since its discovery. In SERS studies, the enhancement of Raman signals fundamentally stems from the electromagnetic field in close vicinity of nanostructures with plasmonic features on a surface. In this context, various innovative methods have been demonstrated recently either using colloidal nanoparticles or 2-D 3-D plasmonic nanostructures. Although utilization of colloidal nanoparticles for SERS applications seems to be a simple and inexpensive procedure, their uncontrolled aggregation leads to a discrepancy in the resulting SERS signals. Despite the significant progress, SERS systems are still facing challenges for practical applications related to their sensitivity, reliability, and selectivity.