Development of Bacteriophage Nanoparticles for Glycomics Analysis by Genetic Engineering
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The study is significant because it has overcome the current bottlenecks in glycan array construction and provide a relatively inexpensive, specific and stable glycan representation method, as well as introduce a simplified and universal purification technique that is not dependent on the carbohydrate. With the development of new glycosylation pathway encoding plasmids, the variety of glycophages can be extended in the future. The basis of glycophage array technology described here should help to expand the diversity of glycan libraries and provide a complement to the existing toolkit for high-throughput analysis of glycan–protein interactions.