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Drosophila Simulans Populasyonlarında Kışlama ile İlgili Gen ve Karakterlerde Enlemsel Varyasyonların Araştırılması
(Fen Bilimleri Enstitüsü, 2020)Clines that are seen in allele frequency and quantitative characters are accepted as evidence of adaptive evolution. Studying the clinal variations is the key of understanding local adaptation. The high adaptation ability ... -
In vitro Şartlarda Mutant AVPR2 Proteinlerinin Yarı Ömür ve Glikozilasyon Özelliklerinin Araştırılması
(Fen Bilimleri Enstitüsü, 2020)Diabetes insipidus (DI) is a disease characterized by excessive urine formation (polyuria) and excessive thirst (polydipsia). DI is classified into gestational DI, primary polydipsia, Nephrogenic DI (NDI), and Central DI ... -
Günlük Hayatta Sıklıkla Kullanılan Fitalatların Metabolitleri Mono Etil Hekzil Fitalat (Mehp) Ve Mono Bütil Fitalatın (Mbp) Olası Etkilerinin in Vıvo ve In Vıtro Yöntemlerle Araştırılması
(Fen Bilimleri Enstitüsü, 2020)Endocrine disruptors are chemicals that have significant effects on the living organism by altering, inhibiting, or mimicking the effects of hormones synthesized by the endocrine system Phthalates are one of the main ... -
Sıçanlarda Bisfenol A İle İndüklenen Polikistik Over Sendromuna Karşı Floretinin Koruyucu Etkilerinin Araştırılması
(Fen Bilimleri Enstitüsü, 2020-09-07)Endocrine disruptors are exogen substance or mixtures that cause an adverse effect in organism or organism’s generation by impacting the function of endocrine system. In this study, it was examined whether phloretin, ... -
Diyabet Modeli Oluşturulan Ins-1e Pankreas Beta Hücrelerinde Neoeriositrinin Koruyucu Etkisinin Araştırılması
(Fen Bilimleri Enstitüsü, 2020)Diabetes is a very common metabolic disease and its incidence has been increasing. In addition to use of drugs in diabetes treatment, plant-based antidiabetic products are also used as alternative. Phytotherapeutic ... -
Türkiye’de Bulunan Kum Sineği Türlerinde (Dıptera: Psychodıdae) Cacophony ve Perıod Gen Bölgelerinin Varyasyonu
(Fen Bilimleri Enstitüsü, 2020)Sand flies are important in transporting many pathogens which are closely related to human and animal health. Specimen identification is the most important step in establishing the vector-pathogen relationship correctly. ... -
Erkek Sıçanlarda Metil Paraben ve Propil Parabenin Birlikte Etkisinin Hipofiz-Adrenal Ekseni Üzerinde İncelenmesi
(Fen Bilimleri Enstitüsü, 2020-01)Propylparaben and methylparaben, which are generally preferred in combination, are chemicals that are used as preservatives in many pharmaceutical, food and cosmetic products. Therefore, we are frequently exposed to parabens ... -
Drosophila melanogaster’de Srl Geninin Egzersiz Fizyolojisi Yanıtlarını Etkileyen Genetik Elementlerin Genom Boylu İlişkilendirme Çalışması ile Saptanması
(Fen Bilimleri Enstitüsü, 2020)In this thesis, it is aimed to determine the processes that affect the expression of the spargel (srl) gene, which is known to have an important role in exercise physiology, and the genes it interacts with. The srl gene, ... -
Drosophıla melanogaster’de Egzersiz Performansı ile İlişkili Ampdeam Geni ile Etkileşen Genomik Varyantların Saptanması
(Fen Bilimleri Enstitüsü, 2020)In this thesis, it is aimed to find out the genes that interact with the AMPdeam gene which has been proven to be associated with exercise performance responses and energy metabolism, in Drosophila melanogaster. For this ... -
Diabetes İnsipidus Tanılı Hastaların AVP-NPII Geninde Tanımlanan Mutasyonların Fonksiyonel Analizleri
(Fen Bilimleri Enstitüsü, 2020)In healthy individuals, blood osmolality is kept within certain limits through mechanisms that regulate body water balance. Thirst is stimulated by sending signals to the kidneys for water protection with an increase in ... -
Kalıtsal Metabolik Hastalıklarda Antioksidan Yanıt ve Otofajinin P62/Nrf2/Keap1 Yolağı Aracılığıyla Araştırılması
(Fen Bilimleri Enstitüsü, 2020-07-08)Due to the enzyme, enzyme cofactor, carrier deficiency or disorder in the metabolic pathways, Inherited Metabolic Diseases (IMDs) cause the accumulation of the substrate and / or end product deficiency that are the single ... -
Oksidatif Stres Karşısında Hava Yolu İnflamatuvar ve Yapısal Hücrelerinde Antioksidan Cevabın Araştırılması
(Fen Bilimleri Enstitüsü, 2020)Free radicals are very short-lived chemical species that contain one or more unshared electrons in their outer orbits. Free radicals, which have a highly reactive structure, act on important components of cells such as ... -
Drosophila Melanogaster’de Ergin Öncesi Yaşam Öyküsü Karakterleri Reaksiyon Normlarının Mevsimselliğinin Araştırılması
(Fen Bilimleri Enstitüsü, 2020)Adaptation ability to varying environmental conditions, makes the organism able to survive. Drosophila melanogaster is a species originated from Africa and spread all around the world. It can live in a wide range of ... -
Seasonality of Genomic Variation in Drosophila melanogaster
(Fen Bilimleri Enstitüsü, 2020)Local adaptation is of fundamental importance in evolutionary biology and understanding the genetic basis of adaptation to new environments has gained importance in recent years. One of the most common organisms for these ... -
Türkiye'de Culex Pipiens Linneaus 1758 (Dıptera:Culıcıdae) Tür Kompleksinin Taksonomik Durumu
(Fen Bilimleri Enstitüsü, 2020-02-21)The morphologically similar members of Culex pipiens species complex differ in their ecophysiology and behaviour. Among them, Culex pipiens pipiens, Cx. p. pallens, Cx. quinquefasciatus and forms of Cx. p. pipiens (molestus ... -
Ankara İli Buprestıdae (Insecta: Coleoptera) Familyası Üzerinde Sistematik Araştırmalar
(Fen Bilimleri Enstitüsü, 2020)In this study, researches were carried out on the family Buprestidae in Ankara province. For this purpose, a total of 69 days of field studies were conducted, 33 days in May-October 2018 and 36 days in April-October 2019. ... -
Farklı Sıcaklıkların Phlebotomus Tobbı Adler, Theodor & Lourıe, 1930 (Dıptera: Psychodıdae) Üzerindeki Etkisinin Hayat Tablosu Verileri ve Gün-Derece Modeliyle Analizi
(Fen Bilimleri Enstitüsü, 2020)Sand flies, known as Bartonellosis and sand fly fever vectors are also the only known vectors of Leishmaniasis, one of the most important protozoan diseases that threaten human and animal health. In the Mediterranean Basin, ... -
Ankara İli Coccınellıdae (Insecta: Coleoptera) Familyası Üzerinde Sistematik Araştırmalar
(Fen Bilimleri Enstitüsü, 2020)In this study, researches was conducted on the family Coccinellidae (Coleoptera) in Ankara province. For this purpose, field studies were carried out in May-October 2018 and April-October 2019 in Ankara. 5310 specimens ... -
Yüksek Çözünürlüklü Genomik Veri ve Numerik Taksonomik Yöntemlerle Noccaea aucheri (Brassicaceae) Tür Kompleksi için Tür Sınırlandırması
(Fen Bilimleri Enstitüsü, 2020)In this study, species limits of N. aucheri species complex which is endemic to serpentine areas of Turkey and transferred from Pseudosempervivum to Noccaea recently were investigated. High-throughput genomic data and ... -
Hayat Tablosu Verileri Kullanarak Elde Edilen Matematiksel Model ve Uygulamaları
(Fen Bilimleri Enstitüsü, 2020)Temperature is the most dominant factor affecting mosquito population dynamics. Life tables quantify the impact of temperature on development durations and mortality rates at different development stages. They provide a ...
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