Eczacılık Fakültesi
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Doksorubisin ve elakridar içeren PLGA/silika hibrit nanopartiküllerin formülasyonu ve meme kanserindeki etkinliğinin değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2019)Although doxorubicin is efficient alone in cancer treatment, its being a substrate of P-glycoprotein (P-gp) limits its effectiveness. Various approaches have been developed to overcome the growing resistance to these drugs. ... -
İnsan Mide Adenokarsinoma Hücrelerinde Helicobacter Pylori'nin Neden Olduğu DNA Çift Sarmal Kırıkları ve Oksidatif Stresin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2019-09-27)Didem, O. Evaluation of DNA Double-Strand Breaks and Oxidative Stress caused by Helicobacter pylori in Human Adenogastric Carcinoma Cells. Hacettepe University Graduate School of Health Sciences, Pharmaceutical Toxicology ... -
Ağızda Dağılan Tablet Formülasyonlarının In Vitro Karakterizasyonları ve Permeabiliteleri Üzerine Farklı Yardımcı Maddelerin ve Basım Tekniklerinin Etkisi
(Sağlık Bilimleri Enstitüsü, 2019)Orally disintegrating tablets are easier and safer to administered in pediatric and geriatrics, patients with difficulty in swallowing and neurological diseases compared with conventional tablets. Orally disintegrating ... -
Meme Kanserinde Hedeflenmiş Metabolitlerin LC-MS/MS Yöntemi ile Tayinleri
(Sağlık Bilimleri Enstitüsü, 2019)The best preventive method for breast cancer, which accounts for 18% of the most common cancer-related deaths among women, is the early diagnosis. Metabolomic analyzes have an important role in early diagnosis and tracking ... -
KONDANSE 1,4-DİHİDROPİRİDİN TÜREVLERİNİN SENTEZİ İLE ANTİMİKROBİYAL VE ANTİOKSİDAN ETKİLERİ ÜZERİNDE ÇALIŞMALAR
(Sağlık Bilimleri Enstitüsü, 2019)BAYDAR, E. The Studies on Synthesis of Condensed 1,4-Dihydropyridine Derivatives and Their Antimicrobial and Antioxidant activities, Hacettepe University, Graduate School of Health Sciences, Master Thesis in Pharmaceutical ... -
YOĞUN BAKIM ÜNİTELERİNDE KOLİSTİN KAN DÜZEYİ İZLEMİ VE DEĞERLENDİRİLMESİ
(Sağlık Bilimleri Enstitüsü, 2019-09-09)To evaluate the influence of the parameters predicted to develop nephrotoxiciy and the incidence of acute renal failure on the development of nephrotoxicity 30 patients who underwent intravenous colistin therapy for at ... -
Kondanse 1,4-Dihidropiridin Türevlerinin Sentezi ve L-/T-Tipi Kalsiyum Kanalları Üzerine Etkileri
(Sağlık Bilimleri Enstitüsü, 2019)1,4-Dihydropyridines (DHPs) are crucial blockers of different calcium channel subtypes and have great therapeutic value against cardiovascular and neurophysiologic conditions. In this thesis, the design and the synthesis ... -
Demans Hastalarında Tedaviye Uyunç Ve Klinik Eczacının Rolü
(Sağlık Bilimleri Enstitüsü, 2019)Due to the increase in the elderly population in the world and in our country, the prevalence of dementia, which is one of the most common diseases in this age group, is rapidly increasing. Early diagnosis and treatment ... -
İnme Geçiren Hastalarda Yaşam Kalitesi ve Tedaviye Uyunç Üzerine Klinik Eczacının Katkısı
(Sağlık Bilimleri Enstitüsü, 2019)Stroke is defined as the sudden onset of a focal neurological problem lasting more than 24 hours, is one of the leading causes of repetitive and disability, affecting the quality of life of the patients negatively, causing ... -
Küçük Hücreli Dışı Akciğer Kanser Hücrelerine Hedeflendirilmiş Kombine İlaç İçeren Teranostik Lipozomların Etkinliğinin İzlenmesi
(Sağlık Bilimleri Enstitüsü, 2019-08)Overall, cancer is a fundamental health issue all around the world. In particular, lung cancer is the type that has the highest incidence and mortality rate. Although several methods including chest x-rays, computed ... -
Kojik Asit Türevi Bileşiklerin Tasarımı, Sentezi ve Melanoma Hücresine Karşı Sitotoksisiteleri ile Tirozinaz İnhibisyonu Etkilerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2019)Tyrosinase is an enzyme that acts as a catalyst in the biosynthesis of melanin pigment, which is found in fungi, in plants and in animals. Overproduction and accumulation of this pigment causes hyperpigmentation, post ... -
Bazı 2-Sübstitüe-1H-Benzimidazol Türevleri Üzerinde Çalışmalar
(Sağlık Bilimleri Enstitüsü, 2019)In this study, 12 (1 of registered in the literature) 2-(1H-benzo[d]imidazol-2-yl)-3-(4-(4-substitutedpiperazin-1- yl)phenyl)acrylonitrile (3a-l) and 3 2-(1H-benzo[d]imidazol-2-yl)-3-(4-(4- substitutedpiperazin-1-yl)p ... -
Afyonkarahisar İli Jeotermal Su Kaynaklarından İzole Edilen Mikroalgal Türler Üzerinde Farmakognozik Araştırmalar
(Sağlık Bilimleri Enstitüsü, 2019)Sensoy, M., Pharmacognosic Researches on Isolated Microalgal Species from Geothermal Springs of Afyonkarahisar Province, Hacettepe University, Graduate School of Health Sciences, Pharmacognosy Programme Master of Science ... -
Ankaferd Hemostat' In Mcf-7 Meme Kanseri Hücre Hattına Etkisinin Proteomik Analizlerle İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2019)Nowadays, a large number of cancer-related research is being conducted, which is one of the most difficult and deadly diseases to treat. Thanks to one of these studies, proteomics analysis, which is one of the omic techniques, ... -
Metabolomik Ve Fluksomik Çalışmalar ile Kolon Kanserinde Kemoterapötiklere Karşı Direncin in Vitro Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2019-06-25)Özen G., In Vitro Analysis of Resistance to Chemotherapeutics in Colon Cancer by Metabolomic and Fluxomic Studies, Hacettepe University Graduate of Health Sciences, Analytical Chemistry Program, Ph.D. Thesis, Ankara, 2019. ... -
Tiroid Hücrelerinde Bisfenol A’nın Toksik Etkileri ve Selenyum Bileşiklerinin Koruyucu Rolünün Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2019)Bisphenol A (BPA) is a chemical compound that is used in the production of polycarbonates and epoxy resins. Humans are widely exposed to this compound by oral, inhalation and dermal routes in daily life. It is known to ... -
Türkiye'de Yetişen Bazı Acanthus L. Türlerinden İlaç Adayı Bileşiklerin İzolasyonu
(Sağlık Bilimleri Enstitüsü, 2019)Sarikaya Aydin, S., Isolation of Drug Candidate Compounds from Some Acanthus L. Species Growing in Turkey, Hacettepe University, Graduate School of Health Sciences, Pharmacognosy Program, Doctor of Philosophy Thesis, ... -
Hedeflendirilmiş Antikanser İlaç Yüklü Polimerik Nanotaşıyıcıların Formülasyonları ve Karakterizasyonları
(Sağlık Bilimleri Enstitüsü, 2019)The distribution of the drugs used in cancer chemotherapy without distinction between the diseased area and the healthy area causes damage to healthy tissue. By using targeted drug delivery systems it is intended to ... -
İnsan Nöroblastoma Hücre Kültüründe Amiloid Beta ile Oluşturulan Alzheimer Hastalığı Modelinde Atorvastatinin Sestrin-2, Sirtuin-1, TPP1 ve LC3B Ekspresyonuna Etkisi.
(Sağlık Bilimleri Enstitüsü, 2019-02)Çelik, H. The Effect of Atorvastatin on Sestrin-2, Sirtuin-1, TPP1 and LC3B in Amyloid Beta Induced Alzheimer’s Disease Model in Human Neuroblastoma Cell Culture. Hacettepe University Graduate School of Health Sciences, ... -
HepG2, Caco-2 ve HT-29 Kanser Hücrelerinde 2D Jel Elektroforez ve MALDI-TOF/TOF-MS) ile Ankaferd Hemostat’ ın İn-Vitro Antineoplastik Etkisinin Proteomik Açıdan Araştırılması
(Sağlık Bilimleri Enstitüsü, 2019)One of the breakthroughs in life sciences has been accomplished through the completion of the human genome project. However, the compose of the entire genome map has also brought a tough task for scientists. This task is ...
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