• DOWN SENDROMUNUN TANISINA YÖNELİK SEÇİLMİŞ METABOLİTLERİN GAZ KROMATOGRAFİSİ KÜTLE SPEKTROMETRİSİ İLE TAYİNİ 

  ÖZKAN, Ece (Sağlık Bilimleri Enstitüsü, 2017-07-14)

  Down Syndrome is a common genetic disorder arising due to the condition that humans having an additional chromosome within 21st chromosome couple. Metabolomics is identification and quantification of small molecule metabolites ...

• Normoksik ve Pulmoner Hipertansif Sıçanlarda İntermedin'in (IMD/AM2) Pulmoner Vasküler Yatağa Etkilerinin İncelenmesi 

  Telli, Gökçen (Sağlık Bilimleri Enstitüsü, 2017-07-10)

  Telli, G., Investigation The Role Of Intermedin/Adrenomedullin2 (IMD/AM2) On Pulmonary Vascular Bed In Normoxic and Pulmonary Hypertensive Rats, Hacettepe University Faculty of Pharmacy Department of Pharmacology Doctor ...

• Investigation of Intracellular Mechanisms of Sphingosine-1-Phosphate (S1P)-Induced Contractions in Detrusor Smooth Muscle of Rats having Cyclophosphamide-Induced Cystitis 

  Anjum, İrfan (Sağlık Bilimleri Enstitüsü, 2017)

  Anjum I., Investigation of Intracellular Mechanisms of Sphingosine-1-Phosphate (S1P)-Induced Contractions in Detrusor Smooth Muscle of Rats having Cyclophosphamide-Induced Cystitis, Hacettepe University, Institute of Health ...

• KEMİK METASTAZLARININ TEDAVİSİNDE ETKİLİ NANOPARTİKÜL FORMÜLASYONLARININ GELİŞTİRİLMESİ, OPTİMİZASYONU VE İN VİTRO DEĞERLENDİRİLMESİ 

  Kozlu, Serhat (Sağlık Bilimleri Enstitüsü, 2017)

  Kozlu, S., Formulation Development, Optimisation and In Vitro Evaluation of Nanoparticles Effective to Bone Methastasis, Hacettepe University Institute of Health Sciences Department of Pharmaceutical Technology Doctor of ...

• REKOMBİNANT GRANÜLOSİT KOLONİ UYARICI FAKTÖRÜN BİYOPOLİMERLERLE ENZİMATİK KONJUGASYONU VE PROTEİNİN ÖZELLİKLERİ ÜZERİNDEKİ ETKİLERİNİN ARAŞTIRILMASI ÜZERİNDE ÇALIŞMALAR 

  KAYA ÖZSAN, AYŞE GÖKSU (Sağlık Bilimleri Enstitüsü, 2017)

  Second generation protein products are studied and products are developed in recent years. Aim of this thesis is to add a new alternative to second generation drug development approaches with filgrastim. For this purpose, ...

• Seramik İşçilerinde Mesleki Maruziyete Bağlı Olası Genotoksik Hasarın Değerlendirilmesi 

  Anlar, Hatice Gül (Sağlık Bilimleri Enstitüsü, 2017)

  Silicon (Si) is the second most abundant element after oxygen that was mainly found in granite, flint, quartz rocks and stones. Exposure to crystalline silica (SiO2) occurs mainly in foundry, processing of diatomaceous ...

• Rumex Crıspus L. Ekstreleri ve Sekonder Metabolitlerinin Mmps İnhibitör Aktiviteleri, Antioksidan Kapasiteleri ve Spf Değerlerinin Araştırılarak, Ciltteki Kollajen Dokuyu Onarıcı Fitokozmetik Ürün Geliştirilmesi 

  UZUN, MİNE (Sağlık Bilimleri Enstitüsü, 2017)

  Uzun, M., Development of Collagenous Tissue Restorative Phytocosmetics on Skin by Investigation of MMPs Inhibitory Activities, Antioxidant Capacities and Spf Values of Rumex crispus L. Extracts and Sekonder Metabolites, ...

• Plantago holosteum Scop. Üzerinde Farmakognozik Araştırmalar 

  Genç, Yasin (Sağlık Bilimleri Enstitüsü, 2017)

  ABSTRACT Genç, Y., Pharmacognostical Investigations on Plantago holosteum Scop., Hacettepe University, Institute of Health Sciences, Pharmacognosy Program, Doctor of Philosophy Thesis, Ankara, 2017. The genus Plantago ...

• Ankara İlinde Reçetelenen İlaçlara Bağlı İstenmeyen Etkilerin İzlenmesi ve Farmakovijilans Konusunda Farkındalığın Artırılması 

  Temiz Nemutlu, Nergiz (Sağlık Bilimleri Enstitüsü, 2017)

  Temiz Nemutlu N. Monitoring the Unintended Effects of Prescribed Drugs in Ankara and Improving the Awareness of Pharmacovigilance. Hacettepe University Institute of Health Sciences, Thesis of Master ...

• Caco2 Kolon Kanseri Hücrelerinde Ultra Performanslı Sıvı Kromatografisi-kütle Spektroskopisi Bazlı Proteomik Çalışmalar 

  KOÇAK, ENGİN (Sağlık Bilimleri Enstitüsü, 2017-01)

  Cancer is the one of the most difficult disease to detect and treat. By omic technologies it has been analyzed at molecular level about cancer. Among the omic technologies Proteomic, has been studied intensively worldwide, ...

• Polimerik Nanopartiküllerin Partikül Büyüklüğüne Bağlı Olarak Hücre İçine Alım Kinetikleri ve Mekanizmaları 

  Şahin, Adem (Sağlık Bilimleri Enstitüsü, 2017)

  In this study, it was aimed to investigate cellular uptake of PLGA and chitosan nanoparticles depending on particle size. For this aim, PLGA and chitosan nanoparticles were prepared by nanoprecipitation and ionic gelation ...

• Piknogenol ve Kurkuminin Çeşitli Kanser Hücre Hatlarında Sisplatin Sitotoksisitesine Etkilerinin İncelenmesi 

  Becit, Merve (Sağlık Bilimleri Enstitüsü, 2017-01-13)

  Pycnogenol from Pinus pinaster and curcumin from Curcuma longa L., are poliphenolic compounds and commonly used in many diseases traditionally due to their high antioxidant properties. Cisplatin, an antineoplastic agent, ...

• Metforminin Bazı Kemoterapötik İlaçlarla Etkileşmesinin İn Vitro Olarak Değerlendirilmesi 

  Ünal, Ayşe Zeynep (Sağlık Bilimleri Enstitüsü, 2016-12-29)

  Metformin is an oral antidiabetic drug widely used in the treatment of type 2 diabetes mellitus. It is stated that diabetes patients have a higher risk of developing different pathologies including cancer than healthy ...

• Deneysel Diyabet Modelinde Hipergliseminin Alzheimer Hastalığı ile İlişkili Proteinler Üzerine Etkisi 

  Kazkayası, İnci (Sağlık Bilimleri Enstitüsü, 2016-12)

  Diabetes mellitus (DM) which is one of the foremost health problems enhances the risk of Alzheimer’s disease (AD) although the molecular mechanisms behind this association remain unclear. In the present study, selective ...

• Medikal Onkoloji Polikliniğinde Tedavi Alan Hastalarda Hedefe Yönelik Tedavi ile İlgili Sorunların Belirlenmesi ve Önlenmesinde Klinik Eczacının Rolü 

  Küçük, Esra (Sağlık Bilimleri Enstitüsü, 2016)

  Cancer is defined as uncontrolled growth of cells, which can invade and spread to other organs and tissues of the body. The primary goal in cancer treatment is to eradicate the cancer. Cancer treatments can be classified ...

• Tirozin Kinaz İnhibitörleri ile Tedavi Edilen Hastalarda Tedavi İzleminde İlaç Etkileşimleri ve Yan Etkilerin Saptanması ve Önlenmesinde Klinik Eczacının Rolü 

  Kamer, Tecen (Sağlık Bilimleri Enstitüsü, 2016)

  The use of tyrosine kinase inhibitors as targeted therapies in cancer treatment becomes prevalent. The aim of this study was to determine and prevent drug-drug interactions and also to reduce side effects of thyrosine ...

• Kök Hücrelerde Olası DNA Hasarı ve Onarımının İn Vitro Değerlendirilmesi 

  Çal, Tuğbagül (Sağlık Bilimleri Enstitüsü, 2016-12-26)

  Stem cells provide an opportunity to analyse the effects of xenobiotic on cell viability, differentiation and cell functions. For this reason, it is suitable alternative for in vitro and in vivo methods. Evaluation of the ...

• Kimyasal Olarak İndüklenmiş Meme Kanseri Modelinde Klorofilin-Cu Kompleksinin Antioksidan Etkinliğinin İncelenmesi 

  Özcan, Mehmet (Sağlık Bilimleri Enstitüsü, 2015)

  Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Investigation show that glutathione and related enzymes are often overexpressed in tumor cells ...

• Metastatik Meme Kanseri Hücrelerinde Mtor Üzerine Etkili Bazı Mekanizmaların Araştırılması 

  Uğur, Merve (Sağlık Bilimleri Enstitüsü, 2013)

  Signal trunsduction pathways play crucial roles in breast cancer pathogenesis. mTOR, which plays a central role in cell proliferation and interacts with several cell components, is selected as a target in MDA-MB- 231 ...

• Nnav1.5 Sodyum Kanalı ve Noç-4 Reseptör Sinyalinin Baskılanmasının İnsan Meme Kanseri Hücrelerinde Çoğalma ve Metastatik Potansiye Üzerine Etkisinin İncelenmesi 

  Çakır Aktaş, Canan (Sağlık Bilimleri Enstitüsü, 2013)

  The incidence of breast cancer is rapidly increasing and it is one of the major causes of death. The molecular changes leading to malignant transformation and metastasis of mammary cells is studied intensively. The expression ...

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