Eczacılık Fakültesi

Küçük Hücreli Dışı Akciğer Kanser Hücrelerine Hedeflendirilmiş Kombine İlaç İçeren Teranostik Lipozomların Etkinliğinin İzlenmesi

Karpuz, Merve (Sağlık Bilimleri Enstitüsü, 2019-08)

Overall, cancer is a fundamental health issue all around the world. In particular, lung cancer is the type that has the highest incidence and mortality rate. Although several methods including chest x-rays, computed ...

KOJİK ASİT TÜREVİ BİLEŞİKLERİN TASARIMI, SENTEZİ VE MELANOMA HÜCRESİNE KARŞI SİTOTOKSİSİTELERİ İLE TİROZİNAZ İNHİBİSYONU ETKİLERİNİN DEĞERLENDİRİLMESİ

Adak, Tuğba (Sağlık Bilimleri Enstitüsü, 2019)

Tyrosinase is an enzyme that acts as a catalyst in the biosynthesis of melanin pigment, which is found in fungi, in plants and in animals. Overproduction and accumulation of this pigment causes hyperpigmentation, post ...

BAZI 2-SÜBSTİTÜE-1H-BENZİMİDAZOL TÜREVLERİ ÜZERİNDE ÇALIŞMALAR

SIRIM, MUSTAFA MERT (Sağlık Bilimleri Enstitüsü, 2019)

In this study, 12 (1 of registered in the literature) 2-(1H-benzo[d]imidazol-2-yl)-3-(4-(4-substitutedpiperazin-1- yl)phenyl)acrylonitrile (3a-l) and 3 2-(1H-benzo[d]imidazol-2-yl)-3-(4-(4- substitutedpiperazin-1-yl)p ...

Afyonkarahisar İli Jeotermal Su Kaynaklarından İzole Edilen Mikroalgal Türler Üzerinde Farmakognozik Araştırmalar

Şensoy, Merve (Sağlık Bilimleri Enstitüsü, 2020)

Sensoy, M., Pharmacognosic Researches on Isolated Microalgal Species from Geothermal Springs of Afyonkarahisar Province, Hacettepe University, Graduate School of Health Sciences, Pharmacognosy Programme Master of Science ...

ANKAFERD HEMOSTAT' IN MCF-7 MEME KANSERİ HÜCRE HATTINA ETKİSİNİN PROTEOMİK ANALİZLERLE İNCELENMESİ

ZEKİ, Özge Cansın (Sağlık Bilimleri Enstitüsü, 2019)

Nowadays, a large number of cancer-related research is being conducted, which is one of the most difficult and deadly diseases to treat. Thanks to one of these studies, proteomics analysis, which is one of the omic techniques, ...

Metabolomik Ve Fluksomik Çalışmalar ile Kolon Kanserinde Kemoterapötiklere Karşı Direncin in Vitro Değerlendirilmesi

ÖZEN, Gürkan (Sağlık Bilimleri Enstitüsü, 2019-06-25)

Özen G., In Vitro Analysis of Resistance to Chemotherapeutics in Colon Cancer by Metabolomic and Fluxomic Studies, Hacettepe University Graduate of Health Sciences, Analytical Chemistry Program, Ph.D. Thesis, Ankara, 2019. ...

Tiroid Hücrelerinde Bisfenol A’nın Toksik Etkileri ve Selenyum Bileşiklerinin Koruyucu Rolünün Değerlendirilmesi

Tan, Erhan (Sağlık Bilimleri Enstitüsü, 2019)

Bisphenol A (BPA) is a chemical compound that is used in the production of polycarbonates and epoxy resins. Humans are widely exposed to this compound by oral, inhalation and dermal routes in daily life. It is known to ...

Türkiye'de Yetişen Bazı Acanthus L. Türlerinden İlaç Adayı Bileşiklerin İzolasyonu

Sarıkaya Aydın, Seçil (Sağlık Bilimleri Enstitüsü, 2019)

Sarikaya Aydin, S., Isolation of Drug Candidate Compounds from Some Acanthus L. Species Growing in Turkey, Hacettepe University, Graduate School of Health Sciences, Pharmacognosy Program, Doctor of Philosophy Thesis, ...

Hedeflendirilmiş Antikanser İlaç Yüklü Polimerik Nanotaşıyıcıların Formülasyonları ve Karakterizasyonları

Öztürk, Naile (Sağlık Bilimleri Enstitüsü, 2019)

The distribution of the drugs used in cancer chemotherapy without distinction between the diseased area and the healthy area causes damage to healthy tissue. By using targeted drug delivery systems it is intended to ...

İnsan Nöroblastoma Hücre Kültüründe Amiloid Beta ile Oluşturulan Alzheimer Hastalığı Modelinde Atorvastatinin Sestrin-2, Sirtuin-1, TPP1 ve LC3B Ekspresyonuna Etkisi.

Çelik, Hande (Sağlık Bilimleri Enstitüsü, 2019-02)

Çelik, H. The Effect of Atorvastatin on Sestrin-2, Sirtuin-1, TPP1 and LC3B in Amyloid Beta Induced Alzheimer’s Disease Model in Human Neuroblastoma Cell Culture. Hacettepe University Graduate School of Health Sciences, ...

HepG2, Caco-2 ve HT-29 Kanser Hücrelerinde 2D Jel Elektroforez ve MALDI-TOF/TOF-MS) ile Ankaferd Hemostat’ ın İn-Vitro Antineoplastik Etkisinin Proteomik Açıdan Araştırılması

NENNİ, Merve (Sağlık Bilimleri Enstitüsü, 2019)

One of the breakthroughs in life sciences has been accomplished through the completion of the human genome project. However, the compose of the entire genome map has also brought a tough task for scientists. This task is ...

Yağ Asidi Amid Hidrolaz (Faah) ve Monoaçil Gliserol Lipaz (Magl) İnhibitörlerinin Farede Deneysel Solunum Yolu İnflamasyonu Üzerindeki Etkileri

Abohalaka, Reshed (Sağlık Bilimleri Enstitüsü, 2019-01-15)

The endocannabinoid system is a modulator of physiological functions in various biological systems including the airways. In the present study the effects of treatment with the inhibitors of endocannabinoid-degrading enzymes ...

Akut Miyeloblastik Lösemilerde Gen Temelli Kanser Biyobelirteçlerin Tespiti Aracılığıyla İlaç Duyarlılığı Altgruplarının Belirlenmesi ve Prognoz Ve Tedaviye Cevabın Öngörülmesi

TÜRK TÜRK, Seyhan (Sağlık Bilimleri Enstitüsü, 2018-12-18)

The aim of this study is to determine the gene-based homogeneous subgroups of acute myeloblastic leukemias using the gene expression profiles of renin angiotensin system, the determination of biomarker potentially genes ...

Karbenoksolon Disodyum İçeren Nanopartikül Formülasyonlarının Tasarımı ve Kortikal Yayılan Depresyona Bağlı Migren Tedavisindeki Etkinliğinin Değerlendirilmesi

ÇOPUR, Tuğba (Sağlık Bilimleri Enstitüsü, 2018)

Recent studies on migraine, one of the most common diseases among neurological diseases, have shown that cortical spreading depolarization waves, cause transient opening of Pannexin-1 mega channels from neuronal cell ...

Development of Nano-Formulatıons Contaınıng Neuroprotectıve Actıve Ingredıent and Evaluatıon of Effıcıency in Perıpheral Nerve Injury Model

HAİDAR, Mohammad Karim (Sağlık Bilimleri Enstitüsü, 2018-11-13)

HAIDAR Mohammad Karim, Development of Nano-formulations Containing Neuroprotective Active Ingredient and Evaluation of Efficiency in Peripheral Nerve Injury Model, Hacettepe University Graduate School of Health Sciences, ...