Browsing Eczacılık Fakültesi by Title
Now showing items 71-90 of 126
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Medikal Onkoloji Polikliniğinde Tedavi Alan Hastalarda Hedefe Yönelik Tedavi ile İlgili Sorunların Belirlenmesi ve Önlenmesinde Klinik Eczacının Rolü
(Sağlık Bilimleri Enstitüsü, 2016)Cancer is defined as uncontrolled growth of cells, which can invade and spread to other organs and tissues of the body. The primary goal in cancer treatment is to eradicate the cancer. Cancer treatments can be classified ... -
Meme Kanseri Tedavisinde Aktif Hedeflendirme Amacıyla Kullanılmak Üzere Nano Boyutlu İlaç Taşıyıcı Sistemlerin (Nanofarmasötikler) Tasarımı, İn Vitro/İn Vivo Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2017-09-15)The aim of an ideal therapy using anticancer molecules is to target tumors selectively without damaging healthy tissues. Tumor specific markers formed by the physiological and morphological changes during the growth of ... -
Metastatik Meme Kanseri Hücrelerinde Mtor Üzerine Etkili Bazı Mekanizmaların Araştırılması
(Sağlık Bilimleri Enstitüsü, 2013)Signal trunsduction pathways play crucial roles in breast cancer pathogenesis. mTOR, which plays a central role in cell proliferation and interacts with several cell components, is selected as a target in MDA-MB- 231 ... -
Metforminin Bazı Kemoterapötik İlaçlarla Etkileşmesinin İn Vitro Olarak Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2016-12-29)Metformin is an oral antidiabetic drug widely used in the treatment of type 2 diabetes mellitus. It is stated that diabetes patients have a higher risk of developing different pathologies including cancer than healthy ... -
Metforminin Sitotoksik, Apoptotik ve Genotoksik Etkilerinin İn Vitro Değerlendirilmesi.
(Sağlık Bilimleri Enstitüsü, 2018)Metformin is a biguanide derivative widely used in the treatment of diabetes mellitus. Recent studies have shown the anticancer properties of metformin. The possible mechanisms of anticancer effects of metformin have ... -
Nnav1.5 Sodyum Kanalı ve Noç-4 Reseptör Sinyalinin Baskılanmasının İnsan Meme Kanseri Hücrelerinde Çoğalma ve Metastatik Potansiye Üzerine Etkisinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2013)The incidence of breast cancer is rapidly increasing and it is one of the major causes of death. The molecular changes leading to malignant transformation and metastasis of mammary cells is studied intensively. The expression ... -
Normoksik ve Pulmoner Hipertansif Sıçanlarda İntermedin'in (IMD/AM2) Pulmoner Vasküler Yatağa Etkilerinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2017-07-10)Telli, G., Investigation The Role Of Intermedin/Adrenomedullin2 (IMD/AM2) On Pulmonary Vascular Bed In Normoxic and Pulmonary Hypertensive Rats, Hacettepe University Faculty of Pharmacy Department of Pharmacology Doctor ... -
Nöropatik Ağrı Tedavisinde İlaç Kullanımının Klinik Eczacı Tarafından İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2018)Neuropathic pain is a chronic problem which requires multidisciplinary approaches for its management. Patients’ adherence to and satisfaction with drug therapies affect the success of pain management which can be improved ... -
Obez Çocuklarda Tiroid Işlev Bozuklukları ve Oksidan Antioksidan Statü Arasındaki Ilişkinin Metabolik Risk Etmenleri ile Birlikte Değerlendirilmesi.
(Sağlık Bilimleri Enstitüsü, 2013)Obesity has been defined as “abnormal or excessive fat accumulation that may impair health” by World Health Organization. Obesity is a chronic illness the prevalence of which has increased in both developed and developing ... -
Ocular drug delivery, retinal drug delivery, dexamethasone, pamam dendrimers, in vivo. Oküler ilaç taşınması, retinaya ilaç taşınması, deksametazon, pamam dendrimer, in vivo
(Sağlık Bilimleri Enstitüsü, 2014)Ocular drug delivery is still a challenge due to its complex structure with many anatomical and physiological barriers. Delivering drugs to the back of the eye is especially harder because of barriers like cornea, sclera, ... -
Organosfatlara Maruziyet Sonrasında Oluşan Protein Eklenti Ürünlerini Tanıyan Monoklonal Antikorun Karakterizasyonu
(Sağlık Bilimleri Enstitüsü, 2018)Organophosphorus (OP) pesticides are irreversible inhibitors of cholinesterases [acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)]. The OPs cause the acute toxic effect by covalent binding to a serine amino ... -
Özgün Heterosiklik Bileşiklerin Glutatyon Transferaz P1-1 İnhibitörleri Olarak Araştırılması ve İnsan Meme Kanser Hücreleri Üzerine Etkilerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2012)The aim of this project is to design inhibitors for GST P1-1 and test their effectiveness on breast cancer cells. For this purpose benzoxazole, benzimidazole, benzothiazole derivative compounds were synthesized. Recombinant ... -
Paklitaksel Nanopartiküllerinin Kalite Tasarımı Ile Geliştirilmesi ve Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2013)Quality by design is an FDA initiative that is a science and knowledge-based approach to pharmaceutical development. The aim of this study was to develop and characterize paclitaxel nanoparticles prepared by o/w ... -
Perflorooktanoik Asitin Sitotoksisite Ve Oksidatif Stres Indükleyici Etkilerinin In Vivo Ve In Vitro Sistemlerde Araştırılması
(Sağlık Bilimleri Enstitüsü, 2015)Perfluorooctanoic acid (PFOA) is a persistent environmental pollutant of toxicological importance. However, its mechanism of toxicity was not well-characterized. The aim of this study was to investigate the possible ... -
Pharmacognostıcal Investıgatıons Oprunus Mahaleb Oıl And Its Kernels
(Sağlık Bilimleri Enstitüsü, 2014)Medicinal plants are getting worthy all over the world due to their therapeutic usage. Among medicinal plants in Turkey, Prunus mahaleb L. ( syn. Cerasus mahaleb L. Mill.) is commonly known as mahlep, mehlep, idris agac, ... -
Phytochemıcal and Pharmacologıcal Studıes on Some Papaver Specıes in Turkey
(Sağlık Bilimleri Enstitüsü, 2017-08-14)Papaver species have been used for treating varieties of diseases including depression for centuries in Anatolia. We screened five Papaver species plant extracts for their antidepressant-like activity in vivo and their ... -
Piknogenol ve Kurkuminin Çeşitli Kanser Hücre Hatlarında Sisplatin Sitotoksisitesine Etkilerinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2017-01-13)Pycnogenol from Pinus pinaster and curcumin from Curcuma longa L., are poliphenolic compounds and commonly used in many diseases traditionally due to their high antioxidant properties. Cisplatin, an antineoplastic agent, ... -
Pitavastatin Sitotoksisitesinin Serviks Kanser Hücre (Hela) Hattında Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2018)Cervical cancer which is one of the most common cancer types in women throughout the world. Investigation of possible and alternative treatment methods of cervical cancer will lead to the discovery of new effective treatment ... -
Plantago holosteum Scop. Üzerinde Farmakognozik Araştırmalar
(Sağlık Bilimleri Enstitüsü, 2017)ABSTRACT Genç, Y., Pharmacognostical Investigations on Plantago holosteum Scop., Hacettepe University, Institute of Health Sciences, Pharmacognosy Program, Doctor of Philosophy Thesis, Ankara, 2017. The genus Plantago ...
