Browsing Eczacılık Fakültesi by Title
Now showing items 92-111 of 140
-
Obez Çocuklarda Tiroid Işlev Bozuklukları ve Oksidan Antioksidan Statü Arasındaki Ilişkinin Metabolik Risk Etmenleri ile Birlikte Değerlendirilmesi.
(Sağlık Bilimleri Enstitüsü, 2013)Obesity has been defined as “abnormal or excessive fat accumulation that may impair health” by World Health Organization. Obesity is a chronic illness the prevalence of which has increased in both developed and developing ... -
Organosfatlara Maruziyet Sonrasında Oluşan Protein Eklenti Ürünlerini Tanıyan Monoklonal Antikorun Karakterizasyonu
(Sağlık Bilimleri Enstitüsü, 2018)Organophosphorus (OP) pesticides are irreversible inhibitors of cholinesterases [acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)]. The OPs cause the acute toxic effect by covalent binding to a serine amino ... -
Özgün Heterosiklik Bileşiklerin Glutatyon Transferaz P1-1 İnhibitörleri Olarak Araştırılması ve İnsan Meme Kanser Hücreleri Üzerine Etkilerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2012)The aim of this project is to design inhibitors for GST P1-1 and test their effectiveness on breast cancer cells. For this purpose benzoxazole, benzimidazole, benzothiazole derivative compounds were synthesized. Recombinant ... -
Paklitaksel Nanopartiküllerinin Kalite Tasarımı Ile Geliştirilmesi ve Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2013)Quality by design is an FDA initiative that is a science and knowledge-based approach to pharmaceutical development. The aim of this study was to develop and characterize paclitaxel nanoparticles prepared by o/w ... -
Perflorooktanoik Asitin Sitotoksisite Ve Oksidatif Stres Indükleyici Etkilerinin In Vivo Ve In Vitro Sistemlerde Araştırılması
(Sağlık Bilimleri Enstitüsü, 2015)Perfluorooctanoic acid (PFOA) is a persistent environmental pollutant of toxicological importance. However, its mechanism of toxicity was not well-characterized. The aim of this study was to investigate the possible ... -
Pharmacognostıcal Investıgatıons Oprunus Mahaleb Oıl And Its Kernels
(Sağlık Bilimleri Enstitüsü, 2014)Medicinal plants are getting worthy all over the world due to their therapeutic usage. Among medicinal plants in Turkey, Prunus mahaleb L. ( syn. Cerasus mahaleb L. Mill.) is commonly known as mahlep, mehlep, idris agac, ... -
Phytochemıcal and Pharmacologıcal Studıes on Some Papaver Specıes in Turkey
(Sağlık Bilimleri Enstitüsü, 2017-08-14)Papaver species have been used for treating varieties of diseases including depression for centuries in Anatolia. We screened five Papaver species plant extracts for their antidepressant-like activity in vivo and their ... -
Piknogenol ve Kurkuminin Çeşitli Kanser Hücre Hatlarında Sisplatin Sitotoksisitesine Etkilerinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2017-01-13)Pycnogenol from Pinus pinaster and curcumin from Curcuma longa L., are poliphenolic compounds and commonly used in many diseases traditionally due to their high antioxidant properties. Cisplatin, an antineoplastic agent, ... -
Pitavastatin Sitotoksisitesinin Serviks Kanser Hücre (Hela) Hattında Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2018)Cervical cancer which is one of the most common cancer types in women throughout the world. Investigation of possible and alternative treatment methods of cervical cancer will lead to the discovery of new effective treatment ... -
Plantago holosteum Scop. Üzerinde Farmakognozik Araştırmalar
(Sağlık Bilimleri Enstitüsü, 2017)ABSTRACT Genç, Y., Pharmacognostical Investigations on Plantago holosteum Scop., Hacettepe University, Institute of Health Sciences, Pharmacognosy Program, Doctor of Philosophy Thesis, Ankara, 2017. The genus Plantago ... -
Polimerik Nanopartiküllerin Partikül Büyüklüğüne Bağlı Olarak Hücre İçine Alım Kinetikleri ve Mekanizmaları
(Sağlık Bilimleri Enstitüsü, 2017)In this study, it was aimed to investigate cellular uptake of PLGA and chitosan nanoparticles depending on particle size. For this aim, PLGA and chitosan nanoparticles were prepared by nanoprecipitation and ionic gelation ... -
Prenatal Bisfenol A ve/veya Di-2-Etil Hekzil Ftalat Maruziyetinin Erkek Üreme Sistemi Üzerine Etkilerinin İncelenmesi.
(Sağlık Bilimleri Enstitüsü, 2018-01)Bisphenol A (BPA) and di (2-ethylhexyl) phthalate (DEHP) are chemical substances that are used in a wide variety of industrial products, with proven endocrine disrupting properties. Today, with the increasing use of these ... -
Prenatal Bisfenol A ve/veya Di-2-Etil Hekzil Ftalat Maruziyetinin Nöroendokrin Bozucu Etkilerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2018)Bisphenol A (BPA) and di(2-ethylhexyl) phthalate (DEHP) are chemical substances that are widely present in the environment and known to have endocine disrupting properties. In the recent years, studies have been conducted ... -
Pterjiumda Neopterin Düzeylerinin ve Kinürenin Yolağının Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2018)Kilicarslan B., Evaluation of Neopterin Levels and Kynurenine Pathway in Pterygium, Hacettepe University Institute of Health Sciences Ph.D. Thesis in Pharmaceutical Toxicology, Ankara, 2018. Pterjium is an inflammatory and ... -
Raloksifen'in Biyolojik Materyalden ve Farmasötik Preparattan Analizi İçin Gaz Kromatografisi-Kütle Spektrometrisi Yönteminin Geliştirilmesi ve Valide Edilmesi
(Sağlık Bilimleri Enstitüsü, 2012)Raloxifene is selective estrogen modulator (SERM) drug which is used in the treatment of postmenopausal osteoporosis in women and used for doping in men. A new gas chromatography-mass spectrometry (GC-MS) method was developed ... -
Rekombinant Granülosit Koloni Uyarıcı Faktörün Biyopolimerlerle Enzimatik Konjugasyonu ve Proteinin Özellikleri Üzerindeki Etkilerinin Araştırılması Üzerinde Çalışmalar
(Sağlık Bilimleri Enstitüsü, 2017)Second generation protein products are studied and products are developed in recent years. Aim of this thesis is to add a new alternative to second generation drug development approaches with filgrastim. For this purpose, ... -
Rivaroksaban Nanokristallerinin Hazırlanması ve İn Vitro - İn Vivo Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2018-04-27)The aim of this thesis is to solve the dose-proportionality problem encountered in high doses as a result of low solubility of rivaroxaban (RXB) which is a direct factor Xa inhibitor and a Biopharmaceutical Classification ... -
Rosa damascena Mill. Farmakope Standartlarının Belirlenmesi, Matriks Metalloproteinaz (MMP) İnhibitör Etkinliklerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2018-03-08)This thesis is summarized as botanical, phytochemical, analytical and biological activity titles. The morphological and anatomical characteristics of Rosa damascena Mill. (Rosaceae) petals have been described in the botanical ... -
Rumex Crıspus L. Ekstreleri ve Sekonder Metabolitlerinin Mmps İnhibitör Aktiviteleri, Antioksidan Kapasiteleri ve Spf Değerlerinin Araştırılarak, Ciltteki Kollajen Dokuyu Onarıcı Fitokozmetik Ürün Geliştirilmesi
(Sağlık Bilimleri Enstitüsü, 2017)Uzun, M., Development of Collagenous Tissue Restorative Phytocosmetics on Skin by Investigation of MMPs Inhibitory Activities, Antioxidant Capacities and Spf Values of Rumex crispus L. Extracts and Sekonder Metabolites, ...
