Browsing Eczacılık Fakültesi by Title
Now showing items 95-114 of 126
-
Raloksifen'in Biyolojik Materyalden ve Farmasötik Preparattan Analizi İçin Gaz Kromatografisi-Kütle Spektrometrisi Yönteminin Geliştirilmesi ve Valide Edilmesi
(Sağlık Bilimleri Enstitüsü, 2012)Raloxifene is selective estrogen modulator (SERM) drug which is used in the treatment of postmenopausal osteoporosis in women and used for doping in men. A new gas chromatography-mass spectrometry (GC-MS) method was developed ... -
Rekombinant Granülosit Koloni Uyarıcı Faktörün Biyopolimerlerle Enzimatik Konjugasyonu ve Proteinin Özellikleri Üzerindeki Etkilerinin Araştırılması Üzerinde Çalışmalar
(Sağlık Bilimleri Enstitüsü, 2017)Second generation protein products are studied and products are developed in recent years. Aim of this thesis is to add a new alternative to second generation drug development approaches with filgrastim. For this purpose, ... -
Rivaroksaban Nanokristallerinin Hazırlanması ve İn Vitro - İn Vivo Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2018-04-27)The aim of this thesis is to solve the dose-proportionality problem encountered in high doses as a result of low solubility of rivaroxaban (RXB) which is a direct factor Xa inhibitor and a Biopharmaceutical Classification ... -
Rosa damascena Mill. Farmakope Standartlarının Belirlenmesi, Matriks Metalloproteinaz (MMP) İnhibitör Etkinliklerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2018-03-08)This thesis is summarized as botanical, phytochemical, analytical and biological activity titles. The morphological and anatomical characteristics of Rosa damascena Mill. (Rosaceae) petals have been described in the botanical ... -
Rumex Crıspus L. Ekstreleri ve Sekonder Metabolitlerinin Mmps İnhibitör Aktiviteleri, Antioksidan Kapasiteleri ve Spf Değerlerinin Araştırılarak, Ciltteki Kollajen Dokuyu Onarıcı Fitokozmetik Ürün Geliştirilmesi
(Sağlık Bilimleri Enstitüsü, 2017)Uzun, M., Development of Collagenous Tissue Restorative Phytocosmetics on Skin by Investigation of MMPs Inhibitory Activities, Antioxidant Capacities and Spf Values of Rumex crispus L. Extracts and Sekonder Metabolites, ... -
Sefiksimin Düşük Çözünürlük ve Permeabilitesinin Siklodekstrin Kompleksleri Kullanılarak Artırılması Üzerine Çalışmalar
(Sağlık Bilimleri Enstitüsü, 2015)Cefixime(SEF) is a wide spectrum antibiotic that is included in the third generation cephalosporins group. Its oral bioavailability is reported to be 40 %. Cyclodextrins have the ability to interact with poorly water-soluble ... -
Sefuroksim Aksetil' in Voltametrik Davranışlarının İncelenmesi ve Elektroanalitik Yöntemlerle Farmasötik Preparatlardan Analizi
(Sağlık Bilimleri Enstitüsü, 2015)In this thesis, square wave voltammetric (SWV) methods have been developed for the quantitative determination of cefuroxime axetil (CEFA) from pharmaceutical preparations. Electrochemical reduction and oxidation of the ... -
Seramik İşçilerinde Mesleki Maruziyete Bağlı Olası Genotoksik Hasarın Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2017)Silicon (Si) is the second most abundant element after oxygen that was mainly found in granite, flint, quartz rocks and stones. Exposure to crystalline silica (SiO2) occurs mainly in foundry, processing of diatomaceous ... -
Serotoninin Renal Hasardaki Rolü
(Sağlık Bilimleri Enstitüsü, 2015)In various acute and chronic renal diseases, tissue damage occurs and platelet activation is observed. Recent studies suggest that some factors released from activated platelets may participate in inflammation and fibrosis ... -
Serviks Kanser Hücre Hattında Timokinonun Sisplatin Sitotoksisitesine Etkilerinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2018)Thymoquinone, derived from the volatile oil of Nigella sativa L. seed known as black seed “çörek otu” in Turkey, is a monoterpene molecule and a bioactive compound. Along with being consumed as food for centuries, thymoquinone ... -
Silikozis Hastalarında Oksisterol Düzeylerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2018)Silicosis is a chronic inflammatory occupational disease that causes permanent and progressive damage to the lungs resulting from prolonged inhalation of silica (SiO2) particles. A significant number of silicosis cases ... -
Sterılızatıon of Grafts Used in Perıodontology by Gamma and Mıcrowave Radıatıon
(Sağlık Bilimleri Enstitüsü, 2018-08-02)BARGH, S, Studies on Sterilization of Grafts Used in Periodontology by Gamma and Microwave Radiation. Hacettepe University, Institute of Health Sciences, Radiopharmacy Program, Master of Science Thesis, Ankara, 2018. The ... -
Studıes on Some Aryloxymethyl Thıosemıcarbazıde, 1,3,4-Thıadıazole And 1,2,4-Trıazole-5-Thıone Derıvatıves
(Sağlık Bilimleri Enstitüsü, 2013)In this study, twelve 1-(7-methoxy-2-naphthyloxyacetyl)-4-subtituted-3-thiosemicarbazide, 5-(7-methoxy-2-naphthyloxymethyl)-2-substituted amino-1,3,4-thiadiazole and 3-(7-methoxy-2-naphthyloxymethyl)-4-substituted- 1,2 ... -
Synthesıs of Condensed 1,4-Dıhydropyrıdıne Derıvatıves And Evaluatıon Of Theır Calcıum Channel Modulatıng and Antıoxıdant Actıvıtıes
(Sağlık Bilimleri Enstitüsü, 2014)In this study, study, a pharmacophore model based on calcium channel blocker ligands was generated by LigandScout and nineteen 2-(methacryloyloxy)ethyl 4-aryl-2,6,6-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate ... -
Sıçan Izole Mezenter Arterinde Kalsiyumsuz Ortamda Elektriksel Alan Uyarısı Ile Elde Edilen Kasılmaların Mekanizmasının Incelenmesi
(Sağlık Bilimleri Enstitüsü, 2014)In the present study, we aimed to examine the effect of blockade of L-type calcium channels (LTCC) and in addition the removal of extracellular calcium, on EFS-induced relaxations in rings of rat mesenteric artery. EFS (30 ... -
Sıçanlarda Adeno İlişkili Viral Vektör Aracılı Gerçekleştirilen Nigral ve Hipokampal Alfasinükleinopati Modelinde Rapamisinin Etkileri
(Sağlık Bilimleri Enstitüsü, 2018)Çınar, E., Effects of Rapamycin In A Rat Model Of Adeno Associated Viral Vector Mediated Nigral and Hippocampal Alpha-synucleinopathy, Hacettepe University Graduate School of Health Sciences, Pharmacology Programme Doctor ... -
Şizofreni ve Benzeri Psikotik Bozukluk Tanısı Almış Hastalara Taburculuk Döneminde İlaç Tedavisine Uyuncunu Arttırmaya Yönelik Olarak Verilen İlaç Eğitiminde Klinik Eczacının Rolü
(Sağlık Bilimleri Enstitüsü, 2017-12-18)The inability to achieve full compliance with drug treatment during the post-discharge period with exacerbations in the illness in patients with schizophrenia and other psychotic disorders is a major problem for the patients ... -
The in Vitro and in Vivo Effects of Telomerase Substrate 6-Thio-2 -Deoxyguanosine
(Sağlık Bilimleri Enstitüsü, 2014)Telomerase mediated telomere targeted therapy represents a new approach in cancer therapy. In this study, I report that the nucleoside analogue 6-thio-2’-deoxyguanosine (6-thio-dG) is recognized by the telomerase ... -
The Protectıve Role Of Escıtalopram On Impared Hıppocampal Neuroplastıcıty Durıng Rem Deprıvatıon
(Sağlık Bilimleri Enstitüsü, 2013)Sleep disorders are mostly associated with psychiatric problems like depression, anxiety disorders, etc. and are thought to be the underlying cause of cognitive deficits observed in these patients. It has been shown that ... -
Tirozin Kinaz İnhibitörleri ile Tedavi Edilen Hastalarda Tedavi İzleminde İlaç Etkileşimleri ve Yan Etkilerin Saptanması ve Önlenmesinde Klinik Eczacının Rolü
(Sağlık Bilimleri Enstitüsü, 2016)The use of tyrosine kinase inhibitors as targeted therapies in cancer treatment becomes prevalent. The aim of this study was to determine and prevent drug-drug interactions and also to reduce side effects of thyrosine ...
