It was investigated a stable formulation development, process understanding and controlling of immediate release Candesartan Cilexetil 32 mg tablet by using QbD approach. Candesartan Cilexetil is a drug substance ...

Free oxygen radicals react with genetic material such as DNA, RNA and other cell macromolecules and the cause oxidative damage. There is a worldwide increasing interest about antioxidant compounds which could delay or ...

Perfluorooctanoic acid (PFOA) is a persistent environmental pollutant of toxicological importance. However, its mechanism of toxicity was not well-characterized. The aim of this study was to investigate the possible ...

Curcuma longa L. rhizomes which are mainly used as spice and for medical purposes in Turkey, are rich in curcumin with (1E, 6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione structure. Three ungrounded rhizomes ...

The genus Gentiana (Gentianaceae) consists species with important phytochemical properties and have been widely used in traditional folk medicine. Iridoids, secoiridoids, C-glycosylflavones and xanthones are considered ...

Medicinal plants are getting worthy all over the world due to their therapeutic usage. Among medicinal plants in Turkey, Prunus mahaleb L. ( syn. Cerasus mahaleb L. Mill.) is commonly known as mahlep, mehlep, idris agac, ...

It has been shown that genetic damage has an improtant role in the mechanisms of cancer and other chronic diseases that have been observed all over the world. Recently, theory about that epigenetic changes are also responsible ...

Ocular drug delivery is still a challenge due to its complex structure with many anatomical and physiological barriers. Delivering drugs to the back of the eye is especially harder because of barriers like cornea, sclera, ...

The aim of this study was to investigate the effect of permeability enhancers on paracellular drug absorption. For this purpose, acyclovir classified as Class III drug (high solubility and low permeability) according to ...

Acetylcholinesterase (AChE) in the serum of fetal bovine is a tetrameric enzyme. The related enzyme, butyrylcholinesterase (BChE), in the sera of humans and horse requires polyproline peptides for assembly into tetramers. ...