Desmin ve Lamin B Etkileşiminin Zebra Balığında Araştırılması
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In this thesis the interaction between desmin, an intermediate filament protein located in cytoplasm and lamin B, intermediate filament protein of the nucleus was investigated using wild type AB zebrafish as a model organism. Within the scope of the thesis, proteins of interest were isolated from wild type AB zebrafish and a direct interaction was determined via co-immunoprecipitation. To confirm the results, proximity ligation assay was used in skeletal muscle sections of wild type AB zebrafish, and a direct interaction between desmin and lamin B was also shown in this technique.