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    • Rational Drug Redesign to Overcome Drug Resistance in Cancer Therapy: Imatinib Moving Target 

      Fernandez, Ariel; Sanguino, Angela; Peng, Zhenghong; Crespo, Alejandro; Ozturk, Eylem; Zhang, Xi; Wang, Shimei; Bornmann, William; Lopez-Berestein, Gabriel (Amer Assoc Cancer Research, 2007)
      Protein kinases are central targets for drug-based cancer treatment. To avoid functional impairment, the cell develops mechanisms of drug resistance, primarily based on adaptive mutations. Redesigning a drug to target a ...