Eczacılık Meslek Bilimleri Bölümü
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Metal Geri Dönüşüm Sektörü Çalışanlarında Kurşun Maruziyetinin Neopterin Düzeylerine Etkisi
(Sağlık Bilimleri Enstitüsü, 2023)Muhammetli S., The Effect of Lead Exposure on Neopterin Levels in Metal Recycling Industry Workers, Hacettepe University Graduate School of Health Sciences Pharmacy Department of Pharmaceutical Toxicology Program Master of ... -
Lavandula stoechas L. subsp. stoechas Üzerinde Biyolojik Aktivite Rehberli Çalışmalar
(Sağlık Bilimleri Enstitüsü, 2023)Lavandula stoechas L. subsp. stoechas known as “karabaş otu” is used for diabetes and central nervous system disorders. This thesis focuses on scientifically validating the traditional usage of L. stoechas subsp. stoechas ... -
EROİNİN GLUTATYON METABOLİZMASI ÜZERİNDEKİ ETKİSİNİN METABOLOMİK DÜZEYDE ARAŞTIRILMASI
(Sağlık Bilimleri Enstitüsü, 2023)Heroin is a substance that is a synthetic opioid derivative with a high addictive potential. Serious toxic effects may occur due to heroin use. Although many different mechanisms are effective in the emergence of these ... -
Alkol Esteri Yapısındaki Yeni Azol Türevlerinin Sentezi, Biyolojik Aktiviteleri, Moleküler Modelleme Çalışmaları ve Yapı-Etki İlişkileri
(Sağlık Bilimleri Enstitüsü, 2023)In this study, various carboxylic acid esters of 1-aryl-2-(1H-imidazol-1-yl/1H-1,2,4-triazol-1-yl)ethanol was synthesized in order to discovery new organic compounds with antimicrobial and anticholinesterase effects; ... -
Multipl Skleroz hastalarında öz yönetim modülünün geliştirilmesi ve değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2023)Appropriate treatment and symptom management in Multiple Sclerosis (MS) can improve the quality of life in patients, limit the impact of disability, and ensure continuity of patients’ social lives. International reports ... -
Opuntia ficus-indica (L.) Miller Meyveleri Üzerinde Farmakognozik Çalışmalar
(Sağlık Bilimleri Enstitüsü, 2023)Opuntia ficus-indica, which grows as a single species in our country, is referred to as "prickly fig", "donkey fig", "İndian fig", "prickly pear" or "kaynana dili" as folk speech and it is popularly known and used as a ... -
MELAZMA TEDAVİSİNDE YENİ YAKLAŞIMLAR VE OLASI TOKSİK ETKİLERİNİN İN VİTRO OLARAK DEĞERLENDİRİLMESİ
(Sağlık Bilimleri Enstitüsü, 2023)Melasma is a chronic, acquired disease that results in the accumulation of brown or gray-brown melanin pigment in the epidermis layer and/or dermis layer, especially in areas where the body is more exposed to sunlight, ... -
ÇOCUKLAR VE EBEVEYNLERİ İÇİN KULLANILACAK ‘İLAÇ TEDAVİSİNE UYUNÇ’ VE ‘İLACA İLİŞKİN HASTA/HASTA YAKINI YAKLAŞIMI’ ÖLÇEKLERİNİN GELİŞTİRİLMESİ VE DEĞERLENDİRİLMESİ
(Sağlık Bilimleri Enstitüsü, 2022)It is known that the prescription rate of psychotropic drugs in adolescents is increasing, and medication adherence is lower in children and adolescents compared to adults. The effectiveness of psychotropic drugs is very ... -
BENZOKSAZOLİNON-HİDRAZON FARMAKOFORU TAŞIYAN DUAL ETKİLİ MAO-AROMATAZ İNHİBİTÖRLERİNİN TASARIMI VE SENTEZİ: İN SİLİKO VE İN VİTRO ÇALIŞMALAR
(Sağlık Bilimleri Enstitüsü, 2022)Taşçi, N., Design and synthesis of dual MAO-Aromatase inhibitors containing benzoxazolinone-hydrazone pharmacophore: In silico and in vitro studies, Hacettepe University, Graduate School of Health Sciences PhD Thesis in ... -
CİNSİYETE DAYALI FARKLILIKLAR AÇISINDAN METİL CIVA VE TİYOMERSALİN TOKSİSİTELERİNİN İNSAN NÖROBLASTOMA HÜCRELERİNDE KARŞILAŞTIRMALI OLARAK DEĞERLENDİRİLMESİ
(Sağlık Bilimleri Enstitüsü, 2022-12-09)Depending on exposure time and concentration, organic mercury compounds cause significant neurotoxic effects, ranging from deterioration in motor development and cognitive activities to severe neuromotor alterations. It ... -
Kanser Hastalarında Erişkin Aşılamada Tutum ve Davranışlar Üzerine Etki Eden Faktörlerin Belirlenmesi ve Eczacı Tarafından Verilen Aşı Eğitiminin Etkisinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2022)Intended vaccination rates with the pneumococcal vaccine in cancer patients have not been reached worldwide. This study was aimed to evaluate the impact of clinical pharmacist-provided education on pneumonia and pneumococcal ... -
Yoğun Bakım Ünitesinde İlaç Kaynaklı Akut Böbrek Yetmezliğinin Önlenmesinde Klinik Eczacının Rolü
(Sağlık Bilimleri Enstitüsü, 2022)Acute renal failure (ARF) is a disorder that is commonly seen in patients in the intensive care unit (ICU) and has a detrimental impact on the patients' clinical prognosis. Drug-induced ARF is often occurring in the clinic. ... -
Yenidoğan Hastalarda İlaç Kaynaklı Sorunlar
(Sağlık Bilimleri Enstitüsü, 2022-11-01)The higher rate of drug-related problems (DRPs) in hospitalized neonates is associated with the diversity of prescribed drugs and differences in age, weight and diagnosis. The aims of this study were (i) to perform risk ... -
Bazı Gentianella Türlerinin Fitokimyasal Analizleri ve Sekonder Metabolitlerinin BDNF (Beyin-Türevli Nörotrofik Faktör) Üzerindeki Etkileri
(Sağlık Bilimleri Enstitüsü, 2022)Gentianella Moench (Gentianaceae) species contain many secondary metabolites such as xanthones, flavonoids and terpenes. Flavonoids have been reported to contribute to the antidepressant effects of many medicinal plants ... -
The Role and Importance of Dorsal And Ventral Hıppocampal Catecholamınergıc Innervatıons in Socıal Memory of Rats
(Sağlık Bilimleri Enstitüsü, 2022)This study aims to investigate the role and importance of the catecholaminergic innervations in the dorsal (DH) and ventral hippocampus (VH) in social memory of rats. Female Wistar rats were injected bilaterally with ... -
Dihidropiridin Türevlerinin Sentezi ve L-/T-Tipi Kalsiyum Kanal Bloke Edici Aktiviteleri
(Sağlık Bilimleri Enstitüsü, 2022-07-19)1,4- Dihydropyridines (DHPs) are the most well known inhibitors of L-type calcium channels and have important therapeutic value against cardiovascular diseases. Since they target different calcium channel subtypes, they ... -
İmidakloprid ve Asetamipridin İn Vitro Sistemler Üzerindeki Toksik Etkilerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2022-06-27)Neonicotinoids, which have received attention in recent years due to their toxic effects on non-target organisms, particularly bees, are a nicotine-derived insecticide group that is widely used in many countries, including ... -
Sistemik Antifungal İlaç Kullanımının Değerlendirilmesi ve Antifungal Yönetim Ekibi Uygulamaları
(Sağlık Bilimleri Enstitüsü, 2022)Implementation of antifungal stewardship (AFS) program aims to reduce inappropriate use of antifungal drugs. The role of AFS program in the appropriate use of antifungal therapy was evaluated in this study. This study was ... -
Aşılarda Kullanılan Koruyucu ve Adjuvan Maddelerin Olası Toksik Etkilerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2022)The World Health Organization defines vaccines as “pharmaceutical products that enable our immune system to recognize and fight pathogens such as viruses and bacteria and protect our body against the diseases caused by ... -
Hekzahidrokinolin Türevlerinin Sentezi, Sitotoksik Özelliklerinin, ROS Oluşturma Potansiyellerinin ve Enflamasyon Mediyatörleri Üzerine Etkilerinin İn Vitro Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2022)In this study, novel 24 compounds with alkyl 2,6,6-trimethyl-4-(disubstituted phenyl)-5-oxo- 1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (Compound 1a-1f, 2a-2f, 3a-3f and 4a-4f) structure which is expected to show ...
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