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Microwave-Assisted Synthesis Of Condensed 1,4-Dihydropyridines As Potential Calcium Channel Modulators 

Ozer, Erdem Kamil; Gunduz, Miyase Gozde; El-Khouly, Ahmed; Sara, Mehmet Yildirim; Simsek, Rahime; Iskit, Alper Bektas; Safak, Osman Cihat (Scientific Technical Research Council Turkey-Tubitak, 2015)
This study reports the design, synthesis, and calcium channel modulatory activity evaluation of a series of 14 novel fused 1,4-dihydropyridine derivatives. The molecular design of the compounds was based on modifications ...

Ethyl 4-(5-Bromo-1H-Indol-3-Yl)-2,6,6-Trimethyl-5-Oxo-1,4,5,6,7,8-Hexa­Hydro­Quinoline-3-Carboxyl­Ate 

Gündüz, Miyase Gözde; Butcher, Ray J.; Öztürk Yildirim, Sema; El-Khouly, Ahmed; Şafak, Cihat; Şimşek, Rahime (2012)
The title compound, C23H25BrN2O3, crystallizes with two independent mol­ecules in the asymmetric unit (Z′ = 2) which differ in the twist of the 5-bromo-1H-indole ring with respect to the plane of the 4-methyl-1,4,5,6,7,8 ...

Ethyl 2,7,7-Trimethyl-4-(1-Methyl-1H-Indol-3-Yl)-5-Oxo-1,4,5,6,7,8-Hexa­Hydro­Quinoline-3-Carboxyl­Ate 

Öztürk Yildirim, Sema; Butcher, Ray J.; Gündüz, Miyase Gözde; El-Khouly, Ahmed; Şimşek, Rahime; Şafak, Cihat (2012)
In the title mol­ecule, C24H28N2O3, the cyclo­hexene ring is in a sofa conformation and the 1,4-dihydro­pyridine ring is in a slight boat conformation. In the indole ring system, the pyrrole and benzene rings form a dihedral ...

9-(5-Bromo-1H-Indol-3-yl)-1,2,3,4,5,6,7,8,9,10-Deca­hydro­acridine-1,8-Dione Dimethyl Sulfoxide Monosolvate 

El-Khouly, Ahmed; Öztürk Yildirim, Sema; Butcher, Ray J.; Şimsek, Rahime; Şafak, Cihat (2012)
In the title compound, C21H19BrN2O2·C2H6OS, the indole ring system is essentially planar, with a maximum deviation of 0.050 (3) Å for the non-bridgehead C atom adjacent to the N atom. The two cyclo­hex-2-enone rings adopt ...

3,3,6,6-Tetra­Methyl-9-(1-Methyl-1H-Indol-2-Yl)-1,2,3,4,5,6,7,8,9,10-Deca­Hydro­Acridine-1,8-Dione 

Öztürk Yildirim, Sema; Butcher, Ray J.; El-Khouly, Ahmed; Safak, Cihat; Şimsek, Rahime (2012)
In the acridine system of the title mol­ecule, C26H30N2O2, both cyclo­hex-2-enone rings adopt sofa conformations. The indole ring system is essentially planar, with a maximum deviation of 0.017 (2) Å for a bridgehead C ...

2,2,7,7-Tetra­Methyl-1,2,3,4,5,6,7,8-Octa­Hydro­Acridine-1,8-Dione 

Öztürk Yildirim, Sema; Butcher, Ray J.; Şimsek, Rahime; El-Khouly, Ahmed; Şafak, Cihat (2012)
The whole molecule of the title compound, C17H21NO2, is generated by twofold rotational symmetry. The N atom and the C and H atoms in position 4 of the pyridine ring lie on the twofold axis. The cyclohexene ring has a sofa ...
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El-Khouly, Ahmed (6)
Butcher, Ray J. (5)Öztürk Yildirim, Sema (5)Şafak, Cihat (4)Şimsek, Rahime (3)Gündüz, Miyase Gözde (2)Şimşek, Rahime (2)Gunduz, Miyase Gozde (1)Iskit, Alper Bektas (1)Ozer, Erdem Kamil (1)... View MoreSubjectChemistry (1)Engineering (1)... View MoreDate Issued2012 (5)2015 (1)Has File(s)Yes (6)

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