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Evaluation Of Dihydropteridine Reductase Activities In Patients With Kidney Failure
(Walter De Gruyter Gmbh, 2013)
End-stage renal disease (ESRD) is the inability of the kidneys to remove waste products from the blood. The most important factors causing ESRD that require hemodialysis are diabetes and hypertension. There are limited ...
Novel Triazolothiadiazines Act As Potent Anticancer Agents In Liver Cancer Cells Through Akt And Ask-1 Proteins
(Pergamon-Elsevier Science Ltd, 2016)
Newly designed triazolothiadiazines incorporating with structural motifs of nonsteroidal analgesic anti-inflammatory drugs were synthesized and screened for their bioactivity against epithelial cancer cells. Compounds with ...
Investigation Of 1377C/T Polymorphism Of The Toll-Like Receptor 3 Among Patients With Chronic Hepatitis B
(Canadian Science Publishing, Nrc Research Press, 2016)
The immunopathogenesis of chronic hepatitis B (CHB) has not been clarified yet. Toll-like receptors (TLR) are a receptor family that initiates immunity with exogenous-endogenous ligands and plays a role in the pathogenesis ...
Low Doses Of Selenium Specifically Stimulate The Repair Of Oxidative Dna Damage In Lncap Prostate Cancer Cells
(Informa Healthcare, 2012)
Epidemiological studies have demonstrated an inverse relationship between selenium (Se) intake and cancer incidence and/or mortality. However, the molecular mechanisms underlying the cancer chemopreventive activity of Se ...
Folate, Neopterin And Kynurenine Pathway In Patients With Statin Therapy
(Walter De Gruyter Gmbh, 2016)
Statins, widely used antihyperlipidemic drugs, also have immunomodulatory properties independent from their lipid lowering effect. Even with slight modulations in the immune system, pteridine levels can display changes. ...
Design, Synthesis And In Vivo/In Vitro Screening Of Novel Chlorokojic Acid Derivatives
(Taylor & Francis Ltd, 2013)
A series of novel Mannich bases of chlorokojic acid (2-chloromethyl-5-hydroxy-4H-pyran-4-one) were synthesized and their biological activities were investigated. Anticonvulsant activity results according to phase-I tests ...
Hplc Method For Naproxen Determination In Human Plasma And Its Application To A Pharmacokinetic Study In Turkey
(Oxford Univ Press Inc, 2014)
A simple high-performance liquid chromatography method has been developed for the determination of naproxen in human plasma. The method was validated on an Ace C18 column using ultraviolet detection. The mobile phase ...
Three Acylated Flavone Glycosides From Sideritis Ozturkii Aytac & Aksoy
(Pergamon-Elsevier Science Ltd, 2004)
From the aerial parts of Sideritis ozturkii, three new flavonoids, chrysoeriol 7-O-[2"'-O-calieoyl-6"'-O-acetyl-beta-D-glucopyranosyl-(1 --> 2)-beta-D-glucopyranoside], chrysoeriol 7-O-[2"'-O-cafeoyl-beta-O-glucopyranosyl-(1 ...
Low Dose Simvastatin Induces Compositional, Structural And Dynamic Changes In Rat Skeletal Extensor Digitorum Longus Muscle Tissue
(Portland Press Ltd, 2010)
Statins are commonly used drugs in the treatment of hypercholesterolaemia. There are many adverse effects of statins on skeletal muscle, but the underlying mechanisms remain unclear. In the present study, the effects of ...
Inhibitory Effect Of The Methanolic Extract Of Verbascum Latisepalum Hub.-Mor. On Endothelium-Dependent Relaxation In Rat Thoracic Aorta
(Walter De Gruyter Gmbh, 2014)
The leaves and flowers of Verbascum species are used to treat respiratory disorders, haemorrhoids, rheumatic pain, and wounds as well as for the treatment of eczema and other types of inflammatory skin conditions in ...
