Eczacılık Teknolojisi Bölümü
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Karaciğerdeki İlaç Dispozisyonu Üzerine Rifampisinin Etkisinin İncelenmesi ve Farmakokinetik Modelleme
(Sağlık Bilimleri Enstitüsü, 2020)Transporter-mediated pharmacokinetics is one of the determinants in hepatic drug disposition and drug-drug interactions. Among several influx (uptake) transporters expressed in the membranes of hepatocytes, hepatic organic ... -
Beyı̇ne Hedeflendı̇rı̇Lmı̇Ş Bevası̇ Zumab YüKlü Nanopartı̇KüLer İLaç TaşIyıcı Sı̇Stemlerı̇N Hazırlanması Ve Etkı̇nlı̇Klerı̇nin Değerlendı̇rı̇Lmesı̇
(Sağlık Bilimleri Enstitüsü, 2020)In this study, in order to target Bevacizumab to the brain, PLGA-PEG nanoparticles conjugated with Anti-CD71 antibodies that bind specifically to transferrin receptors known to be expressed in the blood-brain endothelium ... -
Polisorbat 80 Kaplı, Kurkumin Ve Dosetaksel Yüklü Plga Nanopartiküler Sistemlerin Geliştirilmesi ve Beyin Tümörü Etkinliklerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2020)Seko, I. Synthesis, evaluation of in vitro and in vivo activities of curcumin and docetaxel loaded polysorbate 80 coated PLGA nanoparticulate systems. Hacettepe University Graduate School Health Sciences Institute, ... -
Bakteriyel Keratit Tedavisine Yönelik Besifloksasin Yüklü Oküler İnsertlerin Elektro-Eğirme Yöntemi ile Geliştirilmesi ve Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2020-08-12)Polat, H.K. Development and Evaluation of Besifloxacin HCl Loaded Ocular Inserts by Electro-Spinning Method for Bacterial Keratitis Treatment, Hacettepe University Graduate School of Health Sciences, Pharmaceutical Technology ... -
Keratokonus Tedavisinde Riboflavin’in Girişimsel Olmayan (“Epi-On”) Teknik ile Korneaya Taşınması İçin Oküler İlaç Taşıyıcı Platformların Tasarlanması ve İn Vitro-İn Vivo Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2020-08-13)Aytekin E. Design and In vitro - In vivo Evaluation of Ocular Drug Delivery Platforms for the Delivery of Riboflavin by Noninvasive (“Epi-On”) Technique in the Treatment of Keratoconus, Hacettepe University Graduate School ... -
Spect Radyofarmasötiklerinden 201tlcl’ün Üretimi ve Kalite Kontrolü
(Sağlık Bilimleri Enstitüsü, 2020)In this study, industrial production of 201Tl radioisotope, which is produced for the first time in Turkey, and development of quality control tests of synthesized 201TlCl radiopharmaceutical, research on its test methods ... -
Kolorektal Kanserlerin Lokal Tedavisinde Oral Uygulanabilen Nanopartiküler İlaç Taşıyıcı Sistem Geliştirilmesi ve İn Vitro/İn Vivo Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2020)Anticancer drugs need to be administered via the parenteral route because of limitations arising from their physicochemical properties. Non-specific biodistribution and difficulty in parenteral administration adversely ... -
Determination Of Regional Intestinal Permeability Of Diclofenac And Metoprolol Using A Newly-Developed And Validated High Performance Liquid Chromatographic Method
(Pharmacotherapy Group, 2015)Purpose: To develop a simple and rapid reversed-phase high performance liquid chromatographic (HPLC) method with UV detection for the simultaneous determination of diclofenac, metoprolol tartrate, phenol red and propyl ... -
Design And Characterization Of Nanocrystal Formulations Containing Ezetimibe
(Pharmaceutical Soc Japan, 2011)Ezetimibe is a lipid-lowering compound that selectively inhibits the absorption of cholesterol and related phytosterols from the intestine As ezetimibe is almost Insoluble in water, its bioavailability is too low to be ... -
Dendrimeric Systems And Their Applications In Ocular Drug Delivery
(2013)Ophthalmic drug delivery is one of the most attractive and challenging research area for pharmaceutical scientists and ophthalmologists. Absorption of an ophthalmic drug in conventional dosage forms is seriously limited ... -
Comparison Of Dissolution Profiles Of Commercially Available Lamivudine Tablets
(Dissolution Technologies, Inc, 2015)The aim of this study was to investigate the influence of dissolution medium on the in vitro release of lamivudine (100 mg) from four commercially available lamivudine tablets (one reference and three generic). Three ... -
Characterization Of Protein And Peptide Binding To Nanogels Formed By Differently Charged Chitosan Derivatives
(2013)Chitosan (Chi) is a natural biodegradable cationic polymer with remarkable potency as a vehicle for drug or vaccine delivery. Chi possesses multiple groups, which can be used both for Chi derivatization and for particle ... -
Two Percent Chitosan Mouthwash: A Microbiological And Clinical Comparative Study
(Elsevier Taiwan, 2012)Background/purpose: The aim of this study was to evaluate the microbiological and clinical effects of a chitosan (CH) mouth rinse on plaque inhibition. Materials and methods: Thirty-six healthy participants were recruited. ... -
The Operational Multiple Dosing Half-Life: A Key To Defining Drug Accumulation In Patients And To Designing Extended Release Dosage Forms
(Springer/Plenum Publishers, 2008)Half-life (t (1/2)) is the oldest but least well understood pharmacokinetic parameter, because most definitions are related to hypothetical 1-compartment body models that don't describe most drugs in humans. Alternatively, ... -
Thrombus Localization By Using Streptokinase Containing Vesicular Systems
(Taylor & Francis Ltd, 2006)Our research focused on the preparation of vesicular drug delivery systems, such as liposomes, noisomes, and sphingosomes, for achieving slow release of entrapped proteins in the circulation to increase half-life, to mask ... -
An Overview on Dry Eye Treatment: Approaches for Cyclosporin A Delivery
(2012)Dry eye syndrome (DES, Keratoconjunctivitis sicca) is a common disorder of the tear film caused by decreased tear production or increased evaporation. Changes in tear composition also promote inflammation on the ocular ... -
Preparation and Physicochemical Characterizations of Solid Lipid Nanoparticles Containing Dotap for Dna Delivery
(Scientific Technical Research Council Turkey-Tubitak, 2015)The aim of this study was to prepare and evaluate stable cationic solid lipid nanoparticles (SLNs) as colloidal carriers for gene therapy. SLNs were mainly composed of three different biocompatible and biodegradable matrix ... -
Preparation and In Vitro/In Vivo Evaluation of Microparticle Formulations Containing Meloxicam
(Springer, 2012)In this study, we have formulated chitosan-coated sodium alginate microparticles containing meloxicam (MLX) and aimed to investigate the correlation between in vitro release and in vivo absorbed percentages of meloxicam. ...
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