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The Operational Multiple Dosing Half-Life: A Key To Defining Drug Accumulation In Patients And To Designing Extended Release Dosage Forms
(Springer/Plenum Publishers, 2008)
Half-life (t (1/2)) is the oldest but least well understood pharmacokinetic parameter, because most definitions are related to hypothetical 1-compartment body models that don't describe most drugs in humans. Alternatively, ...
Few Drugs Display Flip-Flop Pharmacokinetics And These Are Primarily Associated With Classes 3 And 4 Of The Bddcs
This study was conducted to determine the number of drugs exhibiting flip-flop pharmacokinetics following oral (p.o.) dosing from immediate-release dosage forms and if they exhibit a common characteristic that may be ...