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The Operational Multiple Dosing Half-Life: A Key To Defining Drug Accumulation In Patients And To Designing Extended Release Dosage Forms
(Springer/Plenum Publishers, 2008)
Half-life (t (1/2)) is the oldest but least well understood pharmacokinetic parameter, because most definitions are related to hypothetical 1-compartment body models that don't describe most drugs in humans. Alternatively, ...
Few Drugs Display Flip-Flop Pharmacokinetics And These Are Primarily Associated With Classes 3 And 4 Of The Bddcs
This study was conducted to determine the number of drugs exhibiting flip-flop pharmacokinetics following oral (p.o.) dosing from immediate-release dosage forms and if they exhibit a common characteristic that may be ...
Determination Of Regional Intestinal Permeability Of Diclofenac And Metoprolol Using A Newly-Developed And Validated High Performance Liquid Chromatographic Method
(Pharmacotherapy Group, 2015)
Purpose: To develop a simple and rapid reversed-phase high performance liquid chromatographic (HPLC) method with UV detection for the simultaneous determination of diclofenac, metoprolol tartrate, phenol red and propyl ...
Comparison Of Dissolution Profiles Of Commercially Available Lamivudine Tablets
(Dissolution Technologies, Inc, 2015)
The aim of this study was to investigate the influence of dissolution medium on the in vitro release of lamivudine (100 mg) from four commercially available lamivudine tablets (one reference and three generic). Three ...