Now showing items 1-6 of 6
The Operational Multiple Dosing Half-Life: A Key To Defining Drug Accumulation In Patients And To Designing Extended Release Dosage Forms
(Springer/Plenum Publishers, 2008)
Half-life (t (1/2)) is the oldest but least well understood pharmacokinetic parameter, because most definitions are related to hypothetical 1-compartment body models that don't describe most drugs in humans. Alternatively, ...
Few Drugs Display Flip-Flop Pharmacokinetics And These Are Primarily Associated With Classes 3 And 4 Of The Bddcs
This study was conducted to determine the number of drugs exhibiting flip-flop pharmacokinetics following oral (p.o.) dosing from immediate-release dosage forms and if they exhibit a common characteristic that may be ...
Preparation And Physicochemical Characterizations Of Solid Lipid Nanoparticles Containing Dotap For Dna Delivery
(Scientific Technical Research Council Turkey-Tubitak, 2015)
The aim of this study was to prepare and evaluate stable cationic solid lipid nanoparticles (SLNs) as colloidal carriers for gene therapy. SLNs were mainly composed of three different biocompatible and biodegradable matrix ...
A Quadruped Study On Chitosan Microspheres Containing Atorvastatin Calcium: Preparation, Characterization, Quantification And In-Vivo Application
(Pharmaceutical Soc Japan, 2010)
Atorvastatin is commonly used as a cholesterol lowering agent in patients. Recently, the neuroprotective effects of atorvastatin became the focus of many research studies. In this study, we have formulated chitosan ...
Design And Characterization Of Nanocrystal Formulations Containing Ezetimibe
(Pharmaceutical Soc Japan, 2011)
Ezetimibe is a lipid-lowering compound that selectively inhibits the absorption of cholesterol and related phytosterols from the intestine As ezetimibe is almost Insoluble in water, its bioavailability is too low to be ...