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Dynamic Phosphometabolomic Profiling of Human Tissues and Transgenic Models By O-18-Assisted P-31 Nmr and Mass Spectrometry
(Amer Physiological Soc, 2012)
Next-generation screening of disease-related metabolomic phenotypes requires monitoring of both metabolite levels and turnover rates. Stable isotope O-18-assisted P-31 nuclear magnetic resonance (NMR) and mass spectrometry ...
P-31 Nmr Correlation Maps Of O-18/O-16 Chemical Shift Isotopic Effects For Phosphometabolite Labeling Studies
Intramolecular correlations among the O-18-labels of metabolic oligophosphates, mapped by J-decoupled P-31 NMR 2D chemical shift correlation spectroscopy, impart stringent constraints to the O-18-isotope distributions over ...
Modulation Of Mitochondrial Complex I Activity Averts Cognitive Decline In Multiple Animal Models Of Familial Alzheimer'S Disease
Development of therapeutic strategies to prevent Alzheimer's disease (AD) is of great importance. We show that mild inhibition of mitochondrial complex I with small molecule CP2 reduces levels of amyloid beta and phospho-Tau ...
18O-Assisted Dynamic Metabolomics for Individualized Diagnostics and Treatment of Human Diseases
Technological innovations and translation of basic discoveries to clinical practice drive advances in medicine. Today's innovative technologies enable comprehensive screening of the genome, transcriptome, proteome, and ...